{"id":"W3095506429","doi":"10.1101/2020.11.06.371286","title":"Mitochondrial pathway polygenic risk scores are associated with Alzheimer’s Disease","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Endophenotype; Pathogenesis; Disease; Oxidative stress; Mitochondrion; Biology; Biological pathway; Bioinformatics; Alzheimer's disease; Neuroscience; Medicine; Genetics; Gene; Pathology; Endocrinology; Cognition; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111272,0.0005857492,0.0004064807,0.001073601,0.0001991816,0.0005970104,0.0002837383,0.0004453789,0.006910668],"category_scores_gemma":[0.003642953,0.0001727721,0.0006199343,0.001124116,0.0003007428,0.0002413241,0.0005887334,0.0004828739,0.0003866839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001187146,"about_ca_system_score_gemma":0.0001683547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001916379,"about_ca_topic_score_gemma":0.001128814,"domain_scores_codex":[0.9991584,0.0003564979,0.00005199516,0.0002428025,0.0001238892,0.00006634522],"domain_scores_gemma":[0.9976628,0.000946037,0.000697709,0.000310687,0.0001718957,0.0002108325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001102958,0.0000417307,0.9795019,0.00005621871,0.001397919,0.0003485116,0.00007157234,0.0006139443,0.003701038,0.0003051984,0.0006942151,0.01216489],"study_design_scores_gemma":[0.00003476731,0.000101188,0.9950488,0.00001487156,0.0003266446,0.0008442916,0.00004568848,0.00165245,0.0005518561,0.001027789,0.000343143,0.000008541427],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944681,0.0007195405,0.002313515,0.0002545796,0.00002181437,0.000007230517,0.001323921,0.00006536642,0.0008259491],"genre_scores_gemma":[0.9983069,0.0001229071,0.0005686848,0.0000192291,0.00001791884,0.000004740912,0.0006224805,0.00000900661,0.0003280484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006910668,"threshold_uncertainty_score":0.02311856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01709622365385238,"score_gpt":0.2168628253941886,"score_spread":0.1997666017403363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}