{"id":"W3095507416","doi":"10.1128/jvi.01969-20","title":"The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase","year":2020,"lang":"en","type":"article","venue":"Journal of Virology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Institute of General Medical Sciences; U.S. Department of Energy","keywords":"Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Betacoronavirus; 2019-20 coronavirus outbreak; Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004532683,0.0001308674,0.0004060297,0.00005812353,0.00009945297,0.00001803034,0.0001944765,0.0001171555,0.0001692699],"category_scores_gemma":[0.0002032804,0.00008629153,0.0002228384,0.0001422323,0.0002288591,0.00006360194,0.00003135155,0.0005338417,0.00009644967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006532117,"about_ca_system_score_gemma":0.0001973489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006054492,"about_ca_topic_score_gemma":0.000004227418,"domain_scores_codex":[0.9986035,0.0001766718,0.0005793752,0.0001368208,0.000254232,0.0002493572],"domain_scores_gemma":[0.9988105,0.0002432609,0.0004418358,0.0001993066,0.0001562066,0.0001489007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004956408,0.00008422889,0.002322539,0.00001818651,0.0002969531,0.0007130387,0.0007964101,0.000008518373,0.8523842,0.0001766198,0.1368235,0.001419452],"study_design_scores_gemma":[0.009786961,0.003405674,0.002778126,0.00005146479,0.0001798736,0.00383045,0.0001467712,0.0008817729,0.4062037,0.002465593,0.5701148,0.0001548394],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8273901,0.001427428,0.0005825605,0.1695896,0.0002936354,0.0001217639,0.000007680616,0.00001469896,0.0005725088],"genre_scores_gemma":[0.9207165,0.0005924458,0.0004438814,0.07741794,0.0007358352,0.00000464117,8.13478e-7,0.00002158291,0.00006634455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4461805,"threshold_uncertainty_score":0.3518866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06252856760727135,"score_gpt":0.3446819701713304,"score_spread":0.2821534025640591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}