{"id":"W3095527452","doi":"10.1089/nat.2020.0893","title":"To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors","year":2020,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"RNA interference; Gene silencing; Folate receptor; Small interfering RNA; Computational biology; Drug delivery; Biology; Cell biology; RNA; Chemistry; Gene; Cancer cell; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003827879,0.0007039392,0.0008227163,0.001853013,0.0002212872,0.0006991563,0.0006328404,0.001012021,0.003048709],"category_scores_gemma":[0.00035631,0.0003454644,0.0004611425,0.001337775,0.0004609907,0.001291467,0.000469488,0.002124544,0.002464274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006797525,"about_ca_system_score_gemma":0.0004690818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769209,"about_ca_topic_score_gemma":0.001369553,"domain_scores_codex":[0.9998634,0.0000256911,0.00001549712,0.00002595248,0.0000530244,0.00001647489],"domain_scores_gemma":[0.9999115,0.00004409,0.00001001147,0.00000331347,0.00002258437,0.000008477898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007811611,0.0001182437,0.0001119293,0.01762687,0.00007467097,0.0004845821,0.0001901937,0.0005002896,0.0154616,0.01595798,0.04221395,0.9071816],"study_design_scores_gemma":[0.00001022382,0.0001111408,0.0001962566,0.00131454,0.00002904817,0.0008332238,0.00003246312,0.00006482016,0.001525559,0.001520117,0.9943487,0.00001388898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002300011,0.9963217,0.0004099176,0.0004289997,0.0003098607,0.000009199712,0.00001471984,0.00001549273,0.002260219],"genre_scores_gemma":[0.0009950375,0.9959952,0.0004323784,0.000481685,0.0001201998,0.00001270456,0.00002101157,0.000003621088,0.001938201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003048709,"threshold_uncertainty_score":0.01019895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05338897267359567,"score_gpt":0.318460614090231,"score_spread":0.2650716414166353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}