{"id":"W3095527452","doi":"10.1089/nat.2020.0893","title":"To Conjugate or to Package? A Look at Targeted siRNA Delivery Through Folate Receptors","year":2020,"lang":"en","type":"review","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"","keywords":"RNA interference; Gene silencing; Folate receptor; Small interfering RNA; Computational biology; Drug delivery; Biology; Cell biology; RNA; Chemistry; Gene; Cancer cell; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001305281,0.0008617553,0.001372847,0.00009549961,0.0001650144,0.000091699,0.001009248,0.0007632663,0.0004720141],"category_scores_gemma":[0.00005292825,0.0006834921,0.0006514436,0.0004179642,0.00007985132,0.000009529899,0.0007691701,0.0003751709,0.002760966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544407,"about_ca_system_score_gemma":0.0003514764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001171806,"about_ca_topic_score_gemma":0.00004425997,"domain_scores_codex":[0.9969283,0.0002068952,0.0007583014,0.001134651,0.0002888817,0.0006829539],"domain_scores_gemma":[0.9981442,0.00003389065,0.0002866104,0.001009822,0.0001733147,0.000352133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005927702,0.00008041633,0.000004895785,0.001001238,0.001593276,0.00007175344,0.0004915332,0.00000315501,0.03932957,0.00001388672,0.02707702,0.9297405],"study_design_scores_gemma":[0.000258954,0.001552888,6.564413e-7,0.0009408146,0.0005535648,0.00004459362,0.00005731659,0.000002944259,0.02157314,0.00001699404,0.9740971,0.0009010194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003978868,0.9918841,0.0005072746,0.0002851302,0.0009632242,0.001344624,0.0003200134,0.00007707204,0.0006397258],"genre_scores_gemma":[0.0008215256,0.9846677,0.001212175,0.008706157,0.0006418767,0.0001178436,0.0004693759,0.0002301373,0.003133277],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9470201,"threshold_uncertainty_score":0.9995616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05338897267359567,"score_gpt":0.318460614090231,"score_spread":0.2650716414166353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}