{"id":"W3095530395","doi":"10.1007/s12015-020-10058-x","title":"Preclinical Studies of MSC-Derived Extracellular Vesicles to Treat or Prevent Graft Versus Host Disease: a Systematic Review of the Literature","year":2020,"lang":"en","type":"review","venue":"Stem Cell Reviews and Reports","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Foundation","keywords":"Medicine; Graft-versus-host disease; Mesenchymal stem cell; Stem cell; Hematopoietic stem cell transplantation; Disease; Transplantation; Extracellular vesicles; Immunology; Internal medicine; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001969438,0.0009412285,0.003759341,0.003662748,0.0002280955,0.001494131,0.001027544,0.001260228,0.003093718],"category_scores_gemma":[0.003131631,0.000367574,0.001735601,0.003091415,0.0004614783,0.001146921,0.0007849438,0.001110635,0.000664523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006589078,"about_ca_system_score_gemma":0.002563302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409915,"about_ca_topic_score_gemma":0.003047283,"domain_scores_codex":[0.9994677,0.0001117157,0.0001560325,0.00007587075,0.0001577682,0.00003089221],"domain_scores_gemma":[0.9978833,0.001389078,0.0003551487,0.00003517911,0.0002691482,0.0000680065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0006041875,0.0001021647,0.0003473207,0.333452,0.001277293,0.0002235625,0.0001052113,0.0003564125,0.003716818,0.001186233,0.0101851,0.6484435],"study_design_scores_gemma":[0.0003720972,0.001255641,0.00376249,0.2273839,0.01410739,0.001939255,0.0003467044,0.0002217671,0.002897556,0.001749457,0.7458386,0.0001251768],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001073605,0.9996181,0.00004247914,0.00005707167,0.00004097579,0.00001022716,0.00003555763,0.000001945355,0.00008636924],"genre_scores_gemma":[0.0004857634,0.9991993,0.0001115253,0.00009011752,0.0000265862,0.000009714944,0.00002554859,7.695475e-7,0.00005055231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003759341,"threshold_uncertainty_score":0.01041555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05441525765859648,"score_gpt":0.3597909870276758,"score_spread":0.3053757293690793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}