{"id":"W3095579319","doi":"10.1101/2020.10.26.20191510","title":"Assessment of <i>ANG</i> variants in Parkinson’s disease","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Verily Life Sciences; Celgene; Pfizer; National Institutes of Health; U.S. Department of Health and Human Services; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health; U.S. Department of Defense","keywords":"Angiogenin; Amyotrophic lateral sclerosis; Parkinson's disease; Disease; LRRK2; Neuroprotection; Genetic association; Medicine; Genotype; Bioinformatics; Single-nucleotide polymorphism; Gene; Genetics; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001353955,0.0004113778,0.0004605864,0.0009904125,0.0004463875,0.001112059,0.0003335862,0.000595411,0.0030391],"category_scores_gemma":[0.002844923,0.0001610467,0.0005059078,0.001150166,0.0002869088,0.0003021905,0.0003449323,0.0005315795,0.0005681008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205107,"about_ca_system_score_gemma":0.0001837939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002333134,"about_ca_topic_score_gemma":0.002107659,"domain_scores_codex":[0.9989819,0.0003182035,0.0001259665,0.0003618067,0.0001485407,0.0000635847],"domain_scores_gemma":[0.9985714,0.0006365087,0.0003579464,0.0001231367,0.000159516,0.0001515002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00153241,0.00005784481,0.9649895,0.0001201229,0.0008129812,0.001265526,0.0002493129,0.0004067006,0.01399068,0.0004036582,0.001397629,0.01477348],"study_design_scores_gemma":[0.00008873998,0.000331744,0.9791431,0.00009525078,0.0008116479,0.004275579,0.0002421,0.001932008,0.005587993,0.001679516,0.005788704,0.00002357944],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880906,0.002091715,0.00264882,0.0003985089,0.00007183139,0.00002604462,0.003513361,0.00006071863,0.003098282],"genre_scores_gemma":[0.9960109,0.0002095568,0.001857222,0.0001350052,0.00004242971,0.00001230631,0.001136784,0.00002673578,0.0005691388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030391,"threshold_uncertainty_score":0.01016676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0569189773151306,"score_gpt":0.351449662025933,"score_spread":0.2945306847108024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}