{"id":"W3095584460","doi":"10.1136/annrheumdis-2020-eular.529","title":"OP0225 TOFACITINIB AS MONOTHERAPY FOLLOWING METHOTREXATE WITHDRAWAL IN PATIENTS WITH PSORIATIC ARTHRITIS PREVIOUSLY TREATED WITH OPEN-LABEL TOFACITINIB + METHOTREXATE: A RANDOMISED, PLACEBO-CONTROLLED SUBSTUDY OF OPAL BALANCE","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Pfizer (Canada); University of Toronto","funders":"Celgene; Gilead Sciences; Pfizer; Amgen","keywords":"Tofacitinib; Medicine; Placebo; Psoriatic arthritis; Internal medicine; Methotrexate; Clinical endpoint; Gastroenterology; Arthritis; Randomized controlled trial; Surgery; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001898258,0.001489724,0.003408707,0.0007067598,0.0006068916,0.001105486,0.0007768176,0.001652718,0.005379539],"category_scores_gemma":[0.00199872,0.0007711506,0.003151135,0.0005979637,0.0009293486,0.001364071,0.0004388999,0.00280507,0.0007960598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000875705,"about_ca_system_score_gemma":0.0007229245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085861,"about_ca_topic_score_gemma":0.006169124,"domain_scores_codex":[0.999167,0.0003769522,0.00007967746,0.0001556696,0.00008431523,0.0001363774],"domain_scores_gemma":[0.9989138,0.0003564732,0.0003239781,0.00007809854,0.00007845469,0.0002491788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.959681,0.005612704,0.003035292,0.002166349,0.005307704,0.00009462108,0.000161877,0.0002553084,0.002876465,0.00008395419,0.0007575799,0.01996715],"study_design_scores_gemma":[0.8796016,0.09676736,0.0166797,0.0001667084,0.004468046,0.0001331495,0.0001176866,0.000383087,0.000395538,0.0001668783,0.00107513,0.00004520978],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982872,0.010506,0.0003785279,0.0003460692,0.0004647097,0.001950631,0.001099758,0.00008630634,0.00229599],"genre_scores_gemma":[0.9927106,0.002627902,0.0005249775,0.0005427222,0.000389441,0.001172491,0.0008317135,0.000009549775,0.001190595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005379539,"threshold_uncertainty_score":0.01799631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03334244674960742,"score_gpt":0.3189558147628077,"score_spread":0.2856133680132003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}