{"id":"W3095606310","doi":"10.1136/practneurol-2020-002633","title":"Anaesthesia and neuromuscular disorders: what a neurologist needs to know","year":2020,"lang":"en","type":"review","venue":"Practical Neurology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"RYR1; Medicine; Malignant hyperthermia; Sedation; General anaesthesia; Anesthesia; Neuromuscular Blocking Agents; Neuromuscular transmission; Neuromuscular disease; Dantrolene; Intensive care medicine; Ryanodine receptor; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001706895,0.0004555116,0.0008132361,0.0001809028,0.00009495643,0.0001314612,0.0002034267,0.0006686388,0.0000299703],"category_scores_gemma":[0.0009018298,0.0004055407,0.0002776268,0.0003474808,0.0001537799,0.00002039454,0.0003591476,0.0006125316,0.0001384417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000055086,"about_ca_system_score_gemma":0.0001173851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000279088,"about_ca_topic_score_gemma":0.000005648992,"domain_scores_codex":[0.9974501,0.0007089321,0.000415528,0.0008917702,0.000153124,0.00038056],"domain_scores_gemma":[0.998862,0.0001197684,0.0001848068,0.0004532342,0.00004432837,0.0003358922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002235358,0.00008508775,0.0000120873,0.0005284837,0.00006756375,0.00008905146,0.00001836237,0.000009276526,0.00003227612,0.0004010492,0.005072173,0.9934611],"study_design_scores_gemma":[0.0001619233,0.001917552,0.00001537507,0.00005383261,0.0002003563,0.0005261909,0.000009199029,0.00006672564,0.00000200341,0.00003372036,0.9967023,0.0003108524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002234736,0.9724848,0.001282885,0.02383343,0.001151201,0.0008142924,0.000007828853,0.00005487834,0.0001472634],"genre_scores_gemma":[0.0003375496,0.98983,0.0001182965,0.008543184,0.0007633272,0.0001055377,0.0001256532,0.00008627441,0.00009016451],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9931502,"threshold_uncertainty_score":0.9998397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085197695683915,"score_gpt":0.3201083827054592,"score_spread":0.28925640574862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}