{"id":"W3095670265","doi":"10.1182/blood-2020-136360","title":"Cytokine Release Syndrome in Patients with Relapsed/Refractory Multiple Myeloma Treated with Ciltacabtagene Autoleucel in the Phase 1b/2 CARTITUDE-1 Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cytokine release syndrome; Medicine; Cytokine; Multiple myeloma; Refractory (planetary science); Internal medicine; Lenalidomide; Oncology; Gastroenterology; Immunology; Cancer; Immunotherapy; Biology; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000922366,0.0003834138,0.0006662332,0.000309269,0.0002307416,0.0005359467,0.0002561024,0.0004244365,0.0009914057],"category_scores_gemma":[0.0007077051,0.0001695258,0.0004571305,0.0003396036,0.0001627813,0.000278058,0.0002648003,0.0005580572,0.0001907048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731601,"about_ca_system_score_gemma":0.0002973883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002658503,"about_ca_topic_score_gemma":0.000484121,"domain_scores_codex":[0.9996878,0.0001083132,0.00003277704,0.00007726497,0.00004737761,0.0000464554],"domain_scores_gemma":[0.9994429,0.0001134603,0.0001849114,0.00003840824,0.00003486421,0.0001853842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.06892516,0.003145987,0.8579679,0.0002809344,0.0006472498,0.002494986,0.0002955979,0.0006659654,0.03511919,0.0001064057,0.001350257,0.0290004],"study_design_scores_gemma":[0.006096277,0.02657336,0.9566338,0.00002708064,0.0003237481,0.003911701,0.0001174457,0.00125387,0.002246207,0.00005022836,0.002746462,0.00001983502],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988281,0.0005117502,0.00008032217,0.00003126765,0.000008671691,0.00006460281,0.0002490483,0.00000749366,0.0002187215],"genre_scores_gemma":[0.9984568,0.0001206019,0.0001666709,0.0001007887,0.0000349274,0.00006638651,0.000891536,0.00000333717,0.0001589236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009914057,"threshold_uncertainty_score":0.004877985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02171824258558571,"score_gpt":0.2716853110438373,"score_spread":0.2499670684582515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}