{"id":"W3095729508","doi":"10.22541/au.159741407.76559359","title":"The Role of Sex, Age and Genetic Polymorphisms of CYP Enzymes on the Pharmacokinetics of Anticholinergic Drugs","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"CYP2D6; Anticholinergic; Pharmacokinetics; CYP2C19; Medicine; Pharmacology; Drug; Adverse effect; Population; Drug metabolism; Pharmacogenetics; Glucuronidation; Clinical pharmacology; Internal medicine; Cytochrome P450; Biology; Genotype; Metabolism; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006305156,0.0002961959,0.0007502056,0.0004505773,0.0001825705,0.0006422514,0.0002733886,0.0004469978,0.00245266],"category_scores_gemma":[0.001819723,0.0001327249,0.0008690357,0.000708177,0.000242255,0.0004976312,0.0002735323,0.0004107137,0.0003595179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232254,"about_ca_system_score_gemma":0.0004495707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237989,"about_ca_topic_score_gemma":0.001514672,"domain_scores_codex":[0.9994998,0.0001639161,0.00008806777,0.00008840359,0.0001115961,0.00004816635],"domain_scores_gemma":[0.9989107,0.0006481091,0.0002532154,0.00002866122,0.000125524,0.00003385482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001744534,0.0001699338,0.1001278,0.01634129,0.002008839,0.003167534,0.0006069579,0.001005252,0.006383861,0.002885506,0.01070735,0.8548512],"study_design_scores_gemma":[0.0001347353,0.001722516,0.5109515,0.006066656,0.004329692,0.02272238,0.00068117,0.0009910432,0.005819387,0.004926222,0.4415127,0.0001421573],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.03698437,0.9555373,0.001165934,0.001177453,0.0003646236,0.00002266811,0.0004598612,0.00002072966,0.004267063],"genre_scores_gemma":[0.1471546,0.8459489,0.001166811,0.0009320949,0.0007922908,0.00004745053,0.0005319745,0.00001608824,0.003409699],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00245266,"threshold_uncertainty_score":0.008204997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06837416206811561,"score_gpt":0.3773067141047014,"score_spread":0.3089325520365858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}