{"id":"W3095746683","doi":"10.1182/blood-2020-137415","title":"Efficacy of Subsequent Novel Targeted Therapies, Including Repeated Venetoclax-Rituximab (VenR), in Patients (Pts) with Relapsed/Refractory Chronic Lymphocytic Leukemia (R/R CLL) Previously Treated with Fixed-Duration Venr in the Murano Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Venetoclax; Bendamustine; Internal medicine; Rituximab; Chronic lymphocytic leukemia; Clinical endpoint; Neutropenia; Progression-free survival; Oncology; Randomized controlled trial; Surgery; Gastroenterology; Chemotherapy; Leukemia; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002163902,0.0004926933,0.001471358,0.0001713281,0.0002088001,0.0006132156,0.0004642024,0.0006550552,0.001973023],"category_scores_gemma":[0.001344869,0.0002621621,0.001557112,0.0001908638,0.0003920992,0.0004963235,0.0003632923,0.001698522,0.0002505601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005896062,"about_ca_system_score_gemma":0.0005041197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003535089,"about_ca_topic_score_gemma":0.001254733,"domain_scores_codex":[0.9993502,0.0003487456,0.00004769258,0.0001170472,0.00005128406,0.00008510567],"domain_scores_gemma":[0.9988513,0.0003248204,0.0004372562,0.0001031757,0.0000400855,0.0002433203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8461272,0.006955068,0.02259532,0.0007524845,0.002349186,0.0001276774,0.0001651566,0.001565232,0.00869811,0.0001883707,0.00143283,0.1090434],"study_design_scores_gemma":[0.3492774,0.5402659,0.09759476,0.000190799,0.003051505,0.0005021479,0.00008329153,0.001552575,0.003054834,0.0003817074,0.004000066,0.00004508255],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955772,0.002900052,0.0001008752,0.0001288291,0.0000431726,0.0002066422,0.0002321232,0.00001151797,0.000799577],"genre_scores_gemma":[0.9972643,0.0008328004,0.0002694195,0.0002036474,0.0000991365,0.0003106481,0.0004482682,0.000003468047,0.0005683567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163902,"threshold_uncertainty_score":0.01144397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603463596912201,"score_gpt":0.2662783070529347,"score_spread":0.2402436710838127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}