{"id":"W3095800501","doi":"10.1101/2020.10.27.357830","title":"Base editing strategy allows insertion of the A673T mutation in APP gene to prevent the development of Alzheimer’s disease","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Weston Brain Institute","keywords":"Amyloid precursor protein; Cytosine deaminase; HEK 293 cells; Gene; Mutation; Biology; Genetics; Alzheimer's disease; Molecular biology; Disease; Medicine; Genetic enhancement; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711701,0.0004884758,0.0002943217,0.0002566277,0.0002603289,0.0003611103,0.0003167943,0.0005489243,0.001484669],"category_scores_gemma":[0.0002518331,0.0001613451,0.0003960984,0.0001661037,0.0003044748,0.000161934,0.0003465057,0.0008081894,0.0008078796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329812,"about_ca_system_score_gemma":0.0002041872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006014775,"about_ca_topic_score_gemma":0.0006234827,"domain_scores_codex":[0.9997521,0.00003927868,0.00003285589,0.00006656164,0.00007791402,0.00003119878],"domain_scores_gemma":[0.9998344,0.00003777664,0.00005482418,0.00002917744,0.00001966522,0.00002405114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003814676,0.00002647717,0.0000842501,0.0000241041,0.000009178852,0.0001271669,0.0000151776,0.0001636046,0.9971219,0.0002715974,0.00009627114,0.002022207],"study_design_scores_gemma":[0.00001195811,0.0001233318,0.0006583806,0.00000682103,0.0000253683,0.0004478429,0.000009804885,0.001828873,0.9906411,0.0000896278,0.006146344,0.00001065028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8850372,0.001413319,0.1013923,0.000354595,0.0003842307,0.0003548149,0.001689129,0.001216954,0.008157419],"genre_scores_gemma":[0.9537464,0.0007315874,0.0368108,0.0001526354,0.00003024449,0.0001407352,0.001165985,0.0002176163,0.007004028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484669,"threshold_uncertainty_score":0.004966676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01605412865752027,"score_gpt":0.2574902063717637,"score_spread":0.2414360777142434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}