{"id":"W3095811344","doi":"10.1182/blood-2020-137451","title":"Preliminary Results of a Phase 2 Study of Camidanlumab Tesirine (Cami), a Novel Pyrrolobenzodiazepine-Based Antibody-Drug Conjugate, in Patients with Relapsed or Refractory Hodgkin Lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Brentuximab vedotin; Internal medicine; Refractory (planetary science); Oncology; Gastroenterology; Lymphoma; Surgery; Hodgkin lymphoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001932325,0.001267326,0.001099988,0.0002721914,0.0003061538,0.0007419201,0.0004993725,0.0009999969,0.002413939],"category_scores_gemma":[0.00125748,0.000347195,0.0008796733,0.0002098035,0.0005368789,0.0007243793,0.0002648972,0.002475843,0.0006756239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005129129,"about_ca_system_score_gemma":0.0007870893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008677528,"about_ca_topic_score_gemma":0.002413144,"domain_scores_codex":[0.9995789,0.000224418,0.00002104812,0.00004791185,0.00003965287,0.00008799724],"domain_scores_gemma":[0.9992969,0.0002306655,0.00009685719,0.00005391896,0.00006414336,0.0002575381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2723511,0.08952563,0.02026312,0.002134661,0.002379971,0.001950598,0.001590317,0.007195976,0.2203751,0.0006186205,0.01431772,0.3672972],"study_design_scores_gemma":[0.2411257,0.6876422,0.03645814,0.00007255415,0.001072162,0.001734507,0.0001538916,0.002584011,0.01847203,0.0005146909,0.01011187,0.00005824277],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843376,0.003525699,0.001747067,0.001181175,0.0001338745,0.002732662,0.00183263,0.0001966165,0.004312723],"genre_scores_gemma":[0.9834062,0.002301333,0.00322212,0.001770588,0.0002298994,0.001829292,0.003804349,0.00006413642,0.003372124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002413939,"threshold_uncertainty_score":0.01021922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211296508800682,"score_gpt":0.2759776509396197,"score_spread":0.2548480000595515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}