{"id":"W3095840616","doi":"10.1177/2472555220965528","title":"E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones","year":2020,"lang":"en","type":"review","venue":"SLAS DISCOVERY","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":369,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"FP7 Ideas: European Research Council; European Commission; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; McGill University","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Drug discovery; Computational biology; Cereblon; Protein degradation; Ubiquitin-Protein Ligases; Proteasome; Chemistry; Biology; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028043,0.001158598,0.001816556,0.001982969,0.0002480895,0.00164917,0.001147167,0.00146558,0.003233084],"category_scores_gemma":[0.0010973,0.0004599789,0.000728143,0.00207057,0.0006613772,0.001845825,0.0008088486,0.002928807,0.002491391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079779,"about_ca_system_score_gemma":0.001246304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032224,"about_ca_topic_score_gemma":0.00248375,"domain_scores_codex":[0.9997579,0.00003253598,0.00002944897,0.0000500285,0.00008395744,0.00004615822],"domain_scores_gemma":[0.9996605,0.0001432406,0.00004681651,0.00001423657,0.00009277408,0.0000424158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002934661,0.00007412447,0.0002322726,0.01481415,0.0001822727,0.0002549528,0.00003474111,0.0006200778,0.003657723,0.00722252,0.05044489,0.9221687],"study_design_scores_gemma":[0.00005115385,0.0001021428,0.0003427392,0.001757703,0.0001718325,0.0007867875,0.00002670601,0.0001582553,0.001425387,0.001803079,0.9933501,0.00002408014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001299298,0.9984505,0.0002679719,0.0003085229,0.0001862809,0.000004947189,0.00003474602,0.00001571519,0.0006013194],"genre_scores_gemma":[0.001004551,0.9970018,0.0003968347,0.0004624724,0.0001397813,0.000009189765,0.00009931147,0.000003908016,0.00088215],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003233084,"threshold_uncertainty_score":0.01081574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03057431257181093,"score_gpt":0.2985406958382705,"score_spread":0.2679663832664596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}