{"id":"W3095840616","doi":"10.1177/2472555220965528","title":"E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones","year":2020,"lang":"en","type":"review","venue":"SLAS DISCOVERY","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":369,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"FP7 Ideas: European Research Council; European Commission; European Federation of Pharmaceutical Industries and Associations; Innovative Medicines Initiative; McGill University","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Drug discovery; Computational biology; Cereblon; Protein degradation; Ubiquitin-Protein Ligases; Proteasome; Chemistry; Biology; Biochemistry; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03057431257181093,"score_gpt":0.2985406958382705,"score_spread":0.2679663832664596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}