{"id":"W3095913111","doi":"10.3390/cancers12113168","title":"O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre National de la Recherche Scientifique; Johns Hopkins University; Ministère de l'Enseignement Supérieur et de la Recherche; Ligue Contre le Cancer; Simon Fraser University; Agence Nationale de la Recherche","keywords":"Downregulation and upregulation; Epigenetics; Carcinogenesis; Colorectal cancer; Cancer research; Medicine; Bioinformatics; Biology; Internal medicine; Cancer; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007570217,0.00007329755,0.00007781707,0.00003244996,0.00008084274,0.00001126227,0.0001214417,0.0001013251,0.00004065017],"category_scores_gemma":[0.00007965611,0.00006367503,0.00004914284,0.0002201292,0.00003287743,0.000003088978,0.00004647118,0.00006690842,0.00001324711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008747756,"about_ca_system_score_gemma":0.0001352036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008292914,"about_ca_topic_score_gemma":0.0001001274,"domain_scores_codex":[0.9993036,0.00005074655,0.0001488799,0.0002004063,0.0001646411,0.0001317397],"domain_scores_gemma":[0.9995505,0.000006120314,0.0000534957,0.0001745819,0.0001289485,0.00008638228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002118911,0.000004977654,0.0007880922,0.00005226868,0.00001369118,3.872538e-7,0.0001754077,0.02183816,0.9743407,0.00001685683,0.00055207,0.00200544],"study_design_scores_gemma":[0.0005007288,0.0002292242,0.03417075,0.00001551712,0.000008864931,9.289529e-7,0.0001057573,0.001720621,0.9472353,0.000009673727,0.0159117,0.0000908992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947571,0.0005193399,0.00189111,0.002027798,0.00004297449,0.0005248715,0.00001967002,0.000007938354,0.0002092305],"genre_scores_gemma":[0.9989199,0.000121707,0.0001651295,0.0002765324,0.0002648663,0.00007810309,0.00006641327,0.00001130514,0.00009604931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03338266,"threshold_uncertainty_score":0.2596592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819786216659057,"score_gpt":0.2646359402052479,"score_spread":0.2464380780386573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}