{"id":"W3095913111","doi":"10.3390/cancers12113168","title":"O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre National de la Recherche Scientifique; Johns Hopkins University; Ministère de l'Enseignement Supérieur et de la Recherche; Ligue Contre le Cancer; Simon Fraser University; Agence Nationale de la Recherche","keywords":"Downregulation and upregulation; Epigenetics; Carcinogenesis; Colorectal cancer; Cancer research; Medicine; Bioinformatics; Biology; Internal medicine; Cancer; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009894512,0.0002243394,0.0001828955,0.0001964044,0.0001235991,0.0002149416,0.0001465504,0.0002212514,0.0008063451],"category_scores_gemma":[0.0001317103,0.0001158849,0.0002461688,0.0001587544,0.0002440736,0.0002096991,0.0002275947,0.0003943989,0.0001430612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655349,"about_ca_system_score_gemma":0.0001493799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007104269,"about_ca_topic_score_gemma":0.001284963,"domain_scores_codex":[0.9999216,0.00001166132,0.000006662421,0.00002259567,0.00001608337,0.00002143918],"domain_scores_gemma":[0.9999261,0.00000912138,0.00003223132,0.000007462274,0.00000884502,0.00001626581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002087015,0.000008191459,0.0006213501,0.00003728799,0.000007696866,0.00004415584,0.00001390274,0.00004359998,0.9977149,0.0000610177,0.00001924008,0.001219889],"study_design_scores_gemma":[0.00001075661,0.0003464888,0.06740952,0.00001315979,0.00003820357,0.000243389,0.00007112306,0.000683193,0.9289584,0.0001293426,0.002087398,0.000009059218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908391,0.004700012,0.002961068,0.0001526163,0.00003008416,0.00001647732,0.0002742309,0.00006893344,0.0009574204],"genre_scores_gemma":[0.9963287,0.00138322,0.0009677928,0.00006894386,0.000007695186,0.00001548719,0.0002169616,0.000008470374,0.001002807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008063451,"threshold_uncertainty_score":0.002697468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819786216659057,"score_gpt":0.2646359402052479,"score_spread":0.2464380780386573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}