{"id":"W3095941038","doi":"10.1182/blood-2020-134964","title":"Gene Body Methylation and Transcriptional Activity in ASXL1-Mutant Chronic Myelomonocytic Leukemia","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"DNA methylation; Biology; Methylation; Transcriptome; Epigenetics; Gene; Genetics; Gene expression profiling; Fold change; Gene expression; Molecular biology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001250288,0.0001373639,0.0001433767,0.0003217468,0.0001481001,0.0001889275,0.00008294956,0.0001920379,0.00114588],"category_scores_gemma":[0.000165534,0.0000842611,0.00009165407,0.0002601822,0.0001675918,0.00009424218,0.0001659383,0.0001822152,0.0001468172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090686,"about_ca_system_score_gemma":0.00008793219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006531765,"about_ca_topic_score_gemma":0.001105232,"domain_scores_codex":[0.9999034,0.000009978507,0.000006629172,0.0000378232,0.00002419238,0.00001782907],"domain_scores_gemma":[0.9999239,0.00001345858,0.00003439622,0.00000646546,0.0000079916,0.00001370523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001219872,0.00003266814,0.118698,0.00009453417,0.00003196505,0.000136741,0.0001536761,0.0003797117,0.870043,0.00005813982,0.0001847547,0.008966814],"study_design_scores_gemma":[0.00004194335,0.0004374689,0.8473778,0.00001592885,0.00005531772,0.001455995,0.0001989421,0.001636202,0.1468705,0.0001884432,0.001710254,0.00001116703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988332,0.0003013161,0.000257945,0.00002146953,0.00000180971,0.000003442907,0.000441868,0.00001066242,0.0001284142],"genre_scores_gemma":[0.9985988,0.0001328208,0.0004049283,0.00002334239,0.000002176751,0.00001005099,0.0006147346,0.000004225141,0.0002089787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114588,"threshold_uncertainty_score":0.003833294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005485146601129,"score_gpt":0.2858747888896138,"score_spread":0.2558199374236025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}