{"id":"W3095967713","doi":"10.1182/blood-2020-134460","title":"Five-Year Follow-Up of Ibrutinib Plus Rituximab Vs Placebo Plus Rituximab for Waldenstrom's Macroglobulinemia: Final Analysis From the Randomized Phase 3 iNNOVATETM Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Royal Victoria Regional Health Centre; Ottawa Hospital; Royal Victoria Hospital; University of Ottawa","funders":"","keywords":"Ibrutinib; Rituximab; Macroglobulinemia; Medicine; Waldenstrom macroglobulinemia; Internal medicine; Placebo; Lymphoplasmacytic Lymphoma; Fludarabine; Oncology; Gastroenterology; Lymphoma; Chronic lymphocytic leukemia; Chemotherapy; Cyclophosphamide; Leukemia; Multiple myeloma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001591963,0.0005222702,0.0031256,0.0002407428,0.000210318,0.00008697096,0.0007841962,0.0002571762,0.0005505338],"category_scores_gemma":[0.002939002,0.0003668098,0.001115712,0.001910634,0.000437562,0.00009829263,0.000402216,0.0006554433,0.00008986753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001371161,"about_ca_system_score_gemma":0.005423889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003193541,"about_ca_topic_score_gemma":0.0001968818,"domain_scores_codex":[0.9949389,0.0004793892,0.001435941,0.0009954823,0.001341298,0.0008090342],"domain_scores_gemma":[0.9949857,0.002460632,0.0004163022,0.00114159,0.0006320754,0.0003637151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9406231,0.01128305,0.000865171,0.0004905611,0.02445424,0.000928906,0.01004851,0.0002521991,0.001741647,0.0001598919,0.007979331,0.001173377],"study_design_scores_gemma":[0.9298639,0.00152847,0.00008322401,0.00008073978,0.01469744,0.00003270415,0.002395732,0.04570919,0.004848593,0.0000356127,0.0004093476,0.0003150667],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879423,0.0007977253,0.001634271,0.002354825,0.0001641048,0.005912561,0.0007735895,0.0001260567,0.0002945125],"genre_scores_gemma":[0.994574,0.00005532775,0.002508711,0.000597714,0.0006661849,0.0004111216,0.0005394035,0.00007904218,0.0005684842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04545699,"threshold_uncertainty_score":0.9998784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770505700756589,"score_gpt":0.3264207176106549,"score_spread":0.288715660603089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}