{"id":"W3095967713","doi":"10.1182/blood-2020-134460","title":"Five-Year Follow-Up of Ibrutinib Plus Rituximab Vs Placebo Plus Rituximab for Waldenstrom's Macroglobulinemia: Final Analysis From the Randomized Phase 3 iNNOVATETM Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Royal Victoria Regional Health Centre; Ottawa Hospital; Royal Victoria Hospital; University of Ottawa","funders":"","keywords":"Ibrutinib; Rituximab; Macroglobulinemia; Medicine; Waldenstrom macroglobulinemia; Internal medicine; Placebo; Lymphoplasmacytic Lymphoma; Fludarabine; Oncology; Gastroenterology; Lymphoma; Chronic lymphocytic leukemia; Chemotherapy; Cyclophosphamide; Leukemia; Multiple myeloma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0101511,0.001823562,0.004175961,0.0005605628,0.0005746284,0.001558897,0.001270366,0.002276149,0.003914309],"category_scores_gemma":[0.005841259,0.0007875744,0.006785573,0.0006070331,0.000908519,0.001395448,0.0009370562,0.004072872,0.0007950705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001227752,"about_ca_system_score_gemma":0.001172752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007944537,"about_ca_topic_score_gemma":0.001364802,"domain_scores_codex":[0.9962191,0.002187718,0.0002749841,0.0005113684,0.0003386496,0.0004681595],"domain_scores_gemma":[0.9956826,0.001302249,0.001319381,0.0004815905,0.0003573734,0.0008567106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9874904,0.001525255,0.002574877,0.0001520365,0.003057128,0.00001905979,0.0000279839,0.0003298377,0.0005816918,0.00003463951,0.0004365454,0.00377063],"study_design_scores_gemma":[0.73004,0.2093549,0.04303845,0.00009515087,0.01282179,0.00009521441,0.00006773086,0.00135329,0.001054224,0.0003780203,0.001638251,0.00006306386],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864476,0.004841992,0.0008603007,0.0004173292,0.0003485336,0.001890428,0.003573715,0.00007252536,0.001547602],"genre_scores_gemma":[0.9898992,0.0008923539,0.0007743011,0.0007033316,0.0003022526,0.002024959,0.004407188,0.00002344776,0.000972998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0101511,"threshold_uncertainty_score":0.05368483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770505700756589,"score_gpt":0.3264207176106549,"score_spread":0.288715660603089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}