{"id":"W3096011484","doi":"10.1371/journal.pgen.1009172","title":"Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Natural Science Foundation of China","keywords":"Biology; Retinal degeneration; Rhodopsin; Endoplasmic-reticulum-associated protein degradation; Ubiquitin; Cell biology; Endoplasmic reticulum; Retinitis pigmentosa; Ubiquitin ligase; Drosophila melanogaster; Unfolded protein response; Mutant; Genetics; Retinal; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00015699,0.0005897892,0.0003365549,0.0004068162,0.0002074964,0.0002686262,0.0002292486,0.0002678881,0.0008386141],"category_scores_gemma":[0.00006856807,0.000213544,0.0003897395,0.0001827356,0.0001950799,0.0001278833,0.0002168447,0.0003822218,0.0002629967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003621092,"about_ca_system_score_gemma":0.0001699095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004485546,"about_ca_topic_score_gemma":0.001361665,"domain_scores_codex":[0.9998957,0.00001455508,0.00001678634,0.00003180267,0.00002609592,0.00001504976],"domain_scores_gemma":[0.999926,0.00001097243,0.00002806861,0.000007544896,0.000005862403,0.00002160364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008571756,0.0000203651,0.0004028309,0.00004499868,0.00001060198,0.0001512782,0.00000676788,0.0001200967,0.9975783,0.00008375005,0.00002929321,0.001465962],"study_design_scores_gemma":[0.00005791259,0.0002320581,0.008154959,0.000007979504,0.00005228056,0.001110678,0.00002868853,0.001596279,0.9854592,0.00004527544,0.003245467,0.000009216501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927469,0.001489598,0.003647805,0.00008479945,0.00002541447,0.00005150381,0.0008435731,0.0001175447,0.0009927609],"genre_scores_gemma":[0.9890083,0.001058041,0.006074432,0.00009023418,0.000006776256,0.00003943438,0.001134949,0.00003295947,0.0025549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008386141,"threshold_uncertainty_score":0.002805412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955337321360917,"score_gpt":0.2464477045313669,"score_spread":0.2268943313177578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}