{"id":"W3096011484","doi":"10.1371/journal.pgen.1009172","title":"Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Natural Science Foundation of China","keywords":"Biology; Retinal degeneration; Rhodopsin; Endoplasmic-reticulum-associated protein degradation; Ubiquitin; Cell biology; Endoplasmic reticulum; Retinitis pigmentosa; Ubiquitin ligase; Drosophila melanogaster; Unfolded protein response; Mutant; Genetics; Retinal; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000625162,0.0001538168,0.0001571379,0.00002967306,0.00003484719,0.0000156815,0.0001686644,0.0001061148,0.00002318921],"category_scores_gemma":[0.0000885524,0.0001578056,0.00004864036,0.0001096537,0.00005377407,0.000003457941,0.0001022465,0.00007649284,0.000005016723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005984767,"about_ca_system_score_gemma":0.00006759758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004298919,"about_ca_topic_score_gemma":0.00001494537,"domain_scores_codex":[0.9989603,0.00003746088,0.0003102178,0.000307405,0.0001881014,0.000196496],"domain_scores_gemma":[0.9995816,0.00001001419,0.0001001477,0.0001527388,0.00006869204,0.0000867917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001208722,0.0001246472,0.01775868,0.00003934716,0.00001221416,0.000001117371,0.0001038092,0.0001951543,0.9790052,0.00002757456,0.002322725,0.0002886631],"study_design_scores_gemma":[0.0008721674,0.0002769701,0.001032647,0.00002534446,0.00001368277,0.000001520643,0.00004771506,0.001680388,0.9927331,0.00003885805,0.003090768,0.0001868407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966522,0.001239318,0.0004850579,0.000622187,0.00004309699,0.000179848,0.00004241076,0.00000878348,0.0007271197],"genre_scores_gemma":[0.9964786,0.0004307012,0.002019657,0.0004634475,0.0001153674,0.0000144002,0.000367157,0.00002311603,0.00008755808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01672603,"threshold_uncertainty_score":0.6435125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955337321360917,"score_gpt":0.2464477045313669,"score_spread":0.2268943313177578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}