{"id":"W3096012551","doi":"10.1007/s00394-020-02421-y","title":"The effect of obesity, macronutrients, fasting and nutritional status on drug-metabolizing cytochrome P450s: a systematic review of current evidence on human studies","year":2020,"lang":"en","type":"review","venue":"European Journal of Nutrition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"CYP1A2; Medicine; Cochrane Library; Pharmacology; Drug metabolism; Drug; CYP3A4; Obesity; CYP2D6; Cytochrome P450; Pharmacokinetics; Physiology; Internal medicine; Metabolism; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002257523,0.001107907,0.006051318,0.00335035,0.0002379813,0.001440658,0.001046591,0.001145633,0.003818633],"category_scores_gemma":[0.006875701,0.0005411875,0.005623222,0.004786255,0.0003917706,0.0009575352,0.0008478772,0.0009105995,0.0002507121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006824606,"about_ca_system_score_gemma":0.002041656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00439778,"about_ca_topic_score_gemma":0.01469101,"domain_scores_codex":[0.9988956,0.0002648682,0.0003991842,0.0001884703,0.0002062436,0.00004564422],"domain_scores_gemma":[0.9951164,0.003745291,0.000798937,0.00005606167,0.0002271336,0.00005612319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0008022657,0.0000500832,0.002538724,0.7876942,0.03208562,0.0001460214,0.0001044985,0.0002879378,0.0005046001,0.0002904976,0.003014104,0.1724815],"study_design_scores_gemma":[0.0009252488,0.0008252007,0.03474074,0.4649178,0.3977597,0.001161185,0.0004101757,0.0003357075,0.0006068813,0.001251911,0.09691744,0.0001481103],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003920775,0.9993312,0.00003593165,0.00004817669,0.00002181935,0.00001056881,0.0001075005,0.000001998556,0.00005074332],"genre_scores_gemma":[0.003967869,0.9955099,0.0001860127,0.000160264,0.00003191063,0.00001492619,0.00008800654,0.000001358311,0.00003980814],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006051318,"threshold_uncertainty_score":0.01277459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2690150939973038,"score_gpt":0.513582368053952,"score_spread":0.2445672740566481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}