{"id":"W3096033732","doi":"10.1182/blood-2020-141389","title":"Perturbations in <i>HNRNPH1</i> Splicing and Abundance Affect Global Splicing and Proliferation in Mantle Cell Lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; Simon Fraser University","funders":"","keywords":"RNA splicing; Minigene; Biology; Alternative splicing; Gene knockdown; Splicing factor; Gene; Exonic splicing enhancer; Genetics; RNA; Cell biology; Cancer research; Messenger RNA; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141967,0.000140416,0.0001470328,0.0002517267,0.00009766873,0.0001901067,0.00009887769,0.0001275077,0.0006396851],"category_scores_gemma":[0.0001590038,0.0001012523,0.0001730471,0.0001757156,0.0001976074,0.0001132637,0.0001113674,0.0002398583,0.0001148473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640226,"about_ca_system_score_gemma":0.0000791748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005374505,"about_ca_topic_score_gemma":0.0007719764,"domain_scores_codex":[0.9999043,0.00001199159,0.000006927979,0.00003338894,0.0000246787,0.000018731],"domain_scores_gemma":[0.9998989,0.00002653382,0.00003930026,0.000007892409,0.00000675871,0.00002051401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566601,0.0000128646,0.004817322,0.00002043108,0.00001129836,0.0000465866,0.00001745847,0.000158824,0.9931163,0.00002500658,0.00002559852,0.001591834],"study_design_scores_gemma":[0.0000265716,0.000600239,0.273683,0.000007695285,0.00006007014,0.0009348863,0.0001181244,0.003625084,0.7195615,0.0001427322,0.001229531,0.00001056378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988111,0.000210252,0.0005659891,0.00001398532,0.000001671171,0.000003076751,0.0002000431,0.00002471205,0.0001690346],"genre_scores_gemma":[0.9981745,0.0001899818,0.0007571449,0.00003314806,0.000002994576,0.0000109348,0.0004670158,0.00001312873,0.0003510929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006396851,"threshold_uncertainty_score":0.002139926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008286941470637537,"score_gpt":0.2389563136809441,"score_spread":0.2306693722103066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}