{"id":"W3096092711","doi":"10.1101/2020.10.28.356139","title":"Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McMaster University","funders":"","keywords":"Effector; Chaperone (clinical); Secretion; Transmembrane domain; Biology; Cell biology; Transmembrane protein; Transport protein; Biochemistry; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009256366,0.0001631593,0.0001544432,0.0001236089,0.0001875222,0.0003508449,0.0002056939,0.0003190323,0.0007732096],"category_scores_gemma":[0.0001924909,0.00007185039,0.0001985262,0.0001223569,0.000142647,0.0001195961,0.0001535081,0.0002528008,0.0006053532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204031,"about_ca_system_score_gemma":0.0001797823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002815048,"about_ca_topic_score_gemma":0.0001857126,"domain_scores_codex":[0.9999535,0.000007584045,0.000004306711,0.000009912007,0.00001349634,0.00001120998],"domain_scores_gemma":[0.9999033,0.00001402723,0.00002927453,0.000009653697,0.00001764597,0.00002607445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364724,0.00007283821,0.00388299,0.00008275498,0.00001541628,0.00100871,0.00003823332,0.0009699455,0.987959,0.001783282,0.0003985191,0.003451836],"study_design_scores_gemma":[0.0001464146,0.0009117777,0.05416073,0.00005270961,0.00006037518,0.003478016,0.0002402328,0.03693917,0.8901432,0.003404782,0.01042619,0.00003639789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949895,0.000679176,0.002849863,0.0001299648,0.0000372422,0.00001351349,0.0001206928,0.00007774077,0.001102342],"genre_scores_gemma":[0.998023,0.0001404133,0.001142993,0.00003460903,0.000009300071,0.000004237539,0.000236614,0.000005630642,0.0004032013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007732096,"threshold_uncertainty_score":0.002586663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670782471238291,"score_gpt":0.2356356249158572,"score_spread":0.2189278002034742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}