{"id":"W3096093584","doi":"10.1039/d0cc06525k","title":"A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging","year":2020,"lang":"en","type":"article","venue":"Chemical Communications","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute","funders":"Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Benzothiazole; Fluorescence; G-quadruplex; Chemistry; Live cell imaging; DNA; Cell; Biophysics; Molecular biology; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009164135,0.0001443829,0.0001486194,0.000009570702,0.0001404382,0.00003345238,0.0006415057,0.00006785429,0.00001370079],"category_scores_gemma":[0.0001287296,0.0001141799,0.0000584648,0.0000708659,0.0001849797,0.000005797178,0.0008026638,0.0003085131,0.000001597978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227452,"about_ca_system_score_gemma":0.00002603049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002487859,"about_ca_topic_score_gemma":0.000006125549,"domain_scores_codex":[0.9991348,0.00008180032,0.0002866506,0.0002603589,0.00009377435,0.0001425981],"domain_scores_gemma":[0.9989153,0.00004497425,0.0001605047,0.000701627,0.0000983925,0.00007923381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006923413,0.0002152816,0.001823052,0.0000393466,0.00003072072,3.308032e-7,0.001728131,0.000002507995,0.9950076,0.00000983567,0.0005227173,0.0005512022],"study_design_scores_gemma":[0.0006002384,0.00005946218,0.0006027783,0.00001177575,0.0000449537,0.000003948648,0.004361195,0.0006719923,0.9913388,0.0000458698,0.002118547,0.0001403799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967538,0.000722945,0.0001206717,0.001502316,0.00001982974,0.0003630197,0.00001103432,0.00001715756,0.000489235],"genre_scores_gemma":[0.9974091,0.0001019073,0.002025348,0.0001892871,0.0001062252,0.00003098635,0.0001074896,0.00001816767,0.00001147351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00366878,"threshold_uncertainty_score":0.4656121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686529422538375,"score_gpt":0.2603918445688894,"score_spread":0.2335265503435057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}