{"id":"W3096107020","doi":"10.1182/blood-2020-142859","title":"A Phase I Pharmacokinetic (PK) and Safety Study of Trph-222 in Patients with Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma (R/R NHL): Dose-Escalation Results","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Pharmacokinetics; Adverse effect; Population; Internal medicine; Gastroenterology; Phases of clinical research; Pharmacodynamics; Refractory (planetary science); Antibody-drug conjugate; Diffuse large B-cell lymphoma; Toxicity; Pharmacology; Lymphoma; Urology; Antibody; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153407,0.0009179722,0.001134787,0.0003144314,0.0002709086,0.0007344038,0.0006148366,0.0006298363,0.001960403],"category_scores_gemma":[0.0007365335,0.0004161235,0.0007307495,0.0002988116,0.0007059631,0.0006119454,0.0002344014,0.002389563,0.0006209636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006553377,"about_ca_system_score_gemma":0.0008869751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004508331,"about_ca_topic_score_gemma":0.001032601,"domain_scores_codex":[0.9996495,0.000181382,0.00001402607,0.00005744753,0.0000419076,0.00005558773],"domain_scores_gemma":[0.9994499,0.00009622051,0.0001124842,0.0000743811,0.00004155453,0.0002254315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3048322,0.1470525,0.02059405,0.0008338356,0.001275206,0.0007290847,0.001004623,0.00784827,0.3104085,0.0004783391,0.005075494,0.1998678],"study_design_scores_gemma":[0.1855212,0.756666,0.02521988,0.00002707435,0.0005376226,0.0008142539,0.0001160959,0.003136341,0.02382323,0.0002745837,0.003814323,0.00004942254],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964813,0.0004441547,0.0006729545,0.0001212091,0.00001937686,0.0009683322,0.0003931146,0.00009272648,0.0008068231],"genre_scores_gemma":[0.9949674,0.000430207,0.001402098,0.0002875589,0.00004885795,0.0009005524,0.0008779977,0.00003205366,0.001053233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001960403,"threshold_uncertainty_score":0.00655818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164718382084827,"score_gpt":0.3111885656063705,"score_spread":0.2895413817855222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}