{"id":"W3096107683","doi":"10.1182/blood-2020-138391","title":"Effect of Prior Treatment with Proteasome Inhibitors on the Efficacy and Safety of Once-Weekly Selinexor, Bortezomib, and Dexamethasone in Comparison with Twice-Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Subgroup Analysis from the Boston Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary; University of Alberta","funders":"","keywords":"Bortezomib; Medicine; Dexamethasone; Carfilzomib; Internal medicine; Multiple myeloma; Proteasome inhibitor; Oncology; Ixazomib; Refractory (planetary science); Regimen; Pharmacology; Hazard ratio; Gastroenterology; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002452393,0.0007903181,0.002714716,0.0005560263,0.0002390585,0.0009820547,0.0005956244,0.0007598418,0.001644242],"category_scores_gemma":[0.00213113,0.0002306136,0.005867688,0.0006465135,0.0003187007,0.0006111265,0.0004809641,0.001009703,0.0002421128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005956556,"about_ca_system_score_gemma":0.0004371746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106757,"about_ca_topic_score_gemma":0.002552518,"domain_scores_codex":[0.9983991,0.0005101285,0.0002829705,0.0003082291,0.0002914688,0.0002081054],"domain_scores_gemma":[0.9982344,0.0005588895,0.0005381791,0.0002392667,0.0001444198,0.0002847509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3507898,0.0009637855,0.5208211,0.001303182,0.05942732,0.0003953706,0.0003480868,0.001724614,0.008520437,0.0001853935,0.002004624,0.05351638],"study_design_scores_gemma":[0.01894602,0.0363848,0.9030967,0.0002555716,0.03216013,0.0005864215,0.0003096453,0.001641895,0.001544411,0.0005033707,0.004489049,0.00008204318],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830536,0.01472996,0.0001541736,0.0001682346,0.00007546201,0.0001020879,0.000871677,0.000009937989,0.0008348108],"genre_scores_gemma":[0.9972773,0.0009052409,0.00008400582,0.0001470546,0.00008059653,0.00006493578,0.001125184,0.000007304029,0.0003084105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002714716,"threshold_uncertainty_score":0.01296961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02753824551358135,"score_gpt":0.2955877824111594,"score_spread":0.268049536897578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}