{"id":"W3096109417","doi":"10.1002/anie.202013975","title":"Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Supramolecular Chemistry and Complexes","field":"Chemistry","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Fundo para o Desenvolvimento das Ciências e da Tecnologia; National Natural Science Foundation of China","keywords":"Biofilm; Pillar; Chemistry; Endocrine disruptor; Combinatorial chemistry; Environmental chemistry; Biochemistry; Biology; Engineering; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103917,0.0003175488,0.0001451121,0.0001485685,0.000120111,0.0001270379,0.0002266253,0.0003302081,0.0005444441],"category_scores_gemma":[0.0001011675,0.000103841,0.0001449416,0.000139737,0.0001264898,0.0001709453,0.0001704755,0.0002888556,0.0001789247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299112,"about_ca_system_score_gemma":0.0001126442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003327242,"about_ca_topic_score_gemma":0.0007180373,"domain_scores_codex":[0.9999385,0.00001010319,0.000004642229,0.00001290969,0.0000171833,0.00001663962],"domain_scores_gemma":[0.999959,0.000006864575,0.00001130325,0.000004450927,0.000007263115,0.00001105239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000256014,0.00001827719,0.00003590745,0.00007330906,0.000003562535,0.00005134943,0.00001754542,0.0002607567,0.9971222,0.0002241506,0.00004345684,0.002123859],"study_design_scores_gemma":[0.00001234994,0.0005073361,0.0007972057,0.000008633534,0.00000801397,0.00008310779,0.00001288447,0.001471408,0.9943221,0.0000551492,0.002709764,0.00001204955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990646,0.001867649,0.004587146,0.00007221378,0.00002795721,0.00004434162,0.000140283,0.00005454299,0.002559759],"genre_scores_gemma":[0.9919417,0.000952594,0.005687349,0.00005194649,0.000009030364,0.00003089989,0.0001522565,0.000007980205,0.001166334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005444441,"threshold_uncertainty_score":0.001821399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021368601088264,"score_gpt":0.2517317151023595,"score_spread":0.2303631140140955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}