{"id":"W3096141131","doi":"10.1182/blood-2020-143221","title":"Single-Cell Transcriptomic Profiling of De Novo and Relapsed Acute Myeloid Leukemia Identifies a Leukemic Stemness Program Shared across Diverse Phenotypes","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University Health Centre; McGill University; Jewish General Hospital","funders":"","keywords":"Biology; Single-cell analysis; Transcriptome; Gene expression profiling; Myeloid leukemia; CD34; Myeloid; Leukemia; Stem cell; Cell; Cancer research; Computational biology; Gene; Molecular biology; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799153,0.0001697819,0.0003498899,0.0003489913,0.000187595,0.0004885459,0.0001710607,0.0002115416,0.0009313355],"category_scores_gemma":[0.0002468134,0.0001234969,0.0002348893,0.0005595546,0.0001769634,0.0001638678,0.0002480016,0.0002533812,0.0004046653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464609,"about_ca_system_score_gemma":0.0002351973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005504196,"about_ca_topic_score_gemma":0.001375835,"domain_scores_codex":[0.9997783,0.00001328105,0.00001099372,0.0001137017,0.00005581909,0.00002798864],"domain_scores_gemma":[0.9998789,0.00002706172,0.00003367459,0.00001483052,0.00002932215,0.00001621054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002822501,0.00002425732,0.02744143,0.0001864931,0.00004943215,0.00009164419,0.0001305536,0.0008493293,0.9579751,0.0002049877,0.0004223395,0.01234212],"study_design_scores_gemma":[0.00003822057,0.0004333096,0.6192971,0.00005805181,0.0001867223,0.001082036,0.0003283355,0.01431881,0.348976,0.0009795965,0.01426263,0.00003905358],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828826,0.0009750126,0.005120163,0.00005721839,0.00001125739,0.00002863369,0.009914551,0.0001705709,0.0008399934],"genre_scores_gemma":[0.9691538,0.0008655751,0.007796862,0.0001108692,0.00001327992,0.00009572727,0.02056358,0.00008533392,0.001314814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009313355,"threshold_uncertainty_score":0.003115594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03187072893759019,"score_gpt":0.2890846632346586,"score_spread":0.2572139342970685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}