{"id":"W3096145151","doi":"10.1182/blood-2020-133988","title":"Shared Expression of CD93 and Other Antigens By AML and Endothelial Cells Highlights a Need for Rational Combinatorial Targeting","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"Chimeric antigen receptor; Cancer research; Progenitor cell; Myeloid leukemia; Haematopoiesis; Leukemia; Bone marrow; CD33; Antigen; Stem cell; Myeloid; Immunology; Immunotherapy; Medicine; Biology; CD34; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003407326,0.0002455956,0.0002634638,0.0001984092,0.0001253693,0.0006600781,0.0002479288,0.0002058806,0.0006770006],"category_scores_gemma":[0.0002932484,0.0001056498,0.0001529088,0.0001993878,0.0002657715,0.0003129116,0.0003313105,0.0005703907,0.0002337832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003704837,"about_ca_system_score_gemma":0.0002045375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002836496,"about_ca_topic_score_gemma":0.0005131285,"domain_scores_codex":[0.9997442,0.00006098725,0.00002192641,0.00004866368,0.00008605191,0.00003818363],"domain_scores_gemma":[0.9998604,0.00003271118,0.00003570348,0.00002715626,0.00002423505,0.00001976717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009410155,0.00005180462,0.001452833,0.00005852133,0.00001467229,0.0001224397,0.00002593725,0.001241583,0.9844358,0.001081248,0.0001194755,0.01130159],"study_design_scores_gemma":[0.00001573327,0.0003327412,0.003016016,0.00001174027,0.00003003761,0.0008541227,0.0000552039,0.002807326,0.9845601,0.0005181746,0.00779192,0.000006757253],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464784,0.003184717,0.04637264,0.0003264405,0.00002038433,0.0001220624,0.0002799045,0.0001752676,0.003040093],"genre_scores_gemma":[0.9836322,0.00136941,0.01359336,0.0001187228,0.0000108064,0.00006167527,0.0003216494,0.00002510244,0.000867068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006770006,"threshold_uncertainty_score":0.00268811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02040231393248832,"score_gpt":0.2702720288376731,"score_spread":0.2498697149051848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}