{"id":"W3096186999","doi":"10.7759/cureus.11224","title":"Immunotherapy Benefit in a Patient With Non-Small Cell Lung Cancer and a Rare BRAF Mutation","year":2020,"lang":"en","type":"article","venue":"Cureus","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba; Research Institute in Oncology and Hematology; University of Winnipeg","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; GlaxoSmithKline; Manitoba Medical Service Foundation; Pfizer; AstraZeneca; Horizon 2020 Framework Programme; Eli Lilly and Company","keywords":"Medicine; Anaplastic lymphoma kinase; Nivolumab; Immunotherapy; Lung cancer; Oncology; Mutation; Epidermal growth factor receptor; Cancer research; Internal medicine; Chemotherapy; Targeted therapy; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000009230158,0.00008609248,0.0001242225,0.00002162693,0.00002923419,0.00001204049,0.00001976845,0.00002883923,0.00006952465],"category_scores_gemma":[0.000002341166,0.00006367786,0.00001661537,0.0001069139,0.00001194173,0.00004942921,0.000007468948,0.00005809993,0.000001849565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001027084,"about_ca_system_score_gemma":0.0001023009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007992259,"about_ca_topic_score_gemma":0.0004795891,"domain_scores_codex":[0.9995632,0.000004174122,0.00009793999,0.0001580302,0.00007471357,0.0001020056],"domain_scores_gemma":[0.9997664,0.0000103081,0.0000394619,0.00007538948,0.00003828491,0.00007017294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002008017,0.001042687,0.6706325,0.0009748927,0.0009262611,0.001547413,0.1633707,0.001808951,0.01237102,0.0001759517,0.002254366,0.1428872],"study_design_scores_gemma":[0.06074829,0.009319617,0.8581045,0.001920911,0.001702373,0.0002531155,0.01134217,0.01787024,0.01764414,0.0001606912,0.01962478,0.001309126],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901252,0.00613506,0.0001378018,0.001589293,0.00003418582,0.0005582802,0.00001962287,0.00001940253,0.001381166],"genre_scores_gemma":[0.9973352,0.0003657003,0.0006917323,0.001228595,0.00003868029,0.0001425632,0.00003057807,0.00001709166,0.0001498834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.187472,"threshold_uncertainty_score":0.2596708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008914664854851305,"score_gpt":0.2721151826229476,"score_spread":0.2632005177680963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}