{"id":"W3096187499","doi":"10.1186/s13058-020-01349-9","title":"Prevalence of germline BRCA mutations in HER2-negative metastatic breast cancer: global results from the real-world, observational BREAKOUT study","year":2020,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System","funders":"Merck Sharp and Dohme; AstraZeneca","keywords":"Medicine; Internal medicine; Breast cancer; Oncology; Metastatic breast cancer; BRCA mutation; Cancer; Surgical oncology; Ovarian cancer; Population; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00136744,0.0002952536,0.0005863025,0.0001623953,0.0002130518,0.00005241947,0.0005795483,0.00006483538,0.001671733],"category_scores_gemma":[0.0003493514,0.0002311112,0.00012827,0.003193973,0.0006265289,0.0002549088,0.0001881126,0.0007802972,0.00003593067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001353252,"about_ca_system_score_gemma":0.002668391,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.175156,"about_ca_topic_score_gemma":0.03322979,"domain_scores_codex":[0.9943408,0.001007918,0.001034656,0.0008736761,0.002129676,0.000613241],"domain_scores_gemma":[0.9959991,0.001187214,0.0003161755,0.000648035,0.001520852,0.0003286055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01136375,0.001199697,0.9609229,0.0002869266,0.0005372724,0.00008973559,0.007221,0.001456478,0.0009430473,0.0002954097,0.005302195,0.01038159],"study_design_scores_gemma":[0.008501672,0.0002272262,0.986077,0.0008003608,0.0001301157,0.00002497705,0.001934144,0.001025657,0.0002833413,0.0005712524,0.0002312844,0.0001930056],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8710503,0.0005499799,0.00002649398,0.09058794,0.0001310431,0.002566143,0.03413999,0.00006070807,0.0008874038],"genre_scores_gemma":[0.9955735,0.0008106152,0.0002751453,0.0009813817,0.0006969325,0.001069802,0.0001497971,0.00004247495,0.000400413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1419262,"threshold_uncertainty_score":0.9992409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1946505126626174,"score_gpt":0.4692230717019279,"score_spread":0.2745725590393104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}