{"id":"W3096214547","doi":"10.3390/diagnostics10110907","title":"Alagille Syndrome: Diagnostic Challenges and Advances in Management","year":2020,"lang":"en","type":"review","venue":"Diagnostics","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Alagille syndrome; JAG1; Cholestasis; Liver biopsy; Medicine; Disease; Bioinformatics; Pathology; Liver disease; Phenotype; Biology; Biopsy; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006377086,0.0004632655,0.001696203,0.0002212159,0.00003023758,0.00001407382,0.0001120864,0.0001864617,0.00003023011],"category_scores_gemma":[0.000834896,0.0003749936,0.0002168956,0.0002529524,0.00005038076,0.00006996078,0.0001645818,0.0002629246,0.0001830915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125609,"about_ca_system_score_gemma":0.0001008666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004133821,"about_ca_topic_score_gemma":0.000005608154,"domain_scores_codex":[0.9982326,0.00006983037,0.0004933189,0.0006135812,0.0002534198,0.0003372523],"domain_scores_gemma":[0.9973198,0.001823242,0.0001383169,0.0003399163,0.00001911442,0.0003595658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003991733,0.0003409857,0.001207511,0.04264235,0.0001838367,0.01617625,0.0000230532,1.227156e-7,7.054619e-11,0.000255035,0.0002304098,0.9389365],"study_design_scores_gemma":[0.0007218138,0.0002332429,0.003707618,0.01673593,0.003772905,0.0002879586,0.00003879991,0.000001777487,5.924079e-9,0.0001198831,0.974084,0.0002960452],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003785817,0.9955387,0.000001219417,0.0001315584,0.0001685617,0.001667494,0.0001490646,0.00005606522,0.00224947],"genre_scores_gemma":[0.0001672692,0.9986221,0.0001385886,0.00006354535,0.00009882059,0.0005307868,0.000254643,0.00006519281,0.00005903856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9738536,"threshold_uncertainty_score":0.9998702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02966836299017711,"score_gpt":0.3214237362527727,"score_spread":0.2917553732625956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}