{"id":"W3096214547","doi":"10.3390/diagnostics10110907","title":"Alagille Syndrome: Diagnostic Challenges and Advances in Management","year":2020,"lang":"en","type":"review","venue":"Diagnostics","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Alagille syndrome; JAG1; Cholestasis; Liver biopsy; Medicine; Disease; Bioinformatics; Pathology; Liver disease; Phenotype; Biology; Biopsy; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007002572,0.0005692244,0.0009964064,0.001516922,0.0002517858,0.0009641084,0.0006346336,0.0009707101,0.002448671],"category_scores_gemma":[0.001436834,0.0001711289,0.0004011635,0.0009248477,0.0004021025,0.001052166,0.000593586,0.00204123,0.001180129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004904579,"about_ca_system_score_gemma":0.001045447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009010581,"about_ca_topic_score_gemma":0.001711077,"domain_scores_codex":[0.9997489,0.00006253523,0.00004351987,0.00003606534,0.00008544439,0.00002360576],"domain_scores_gemma":[0.9994825,0.0002955117,0.00005596854,0.00001195226,0.0001150409,0.00003884333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005443724,0.00003684248,0.0004910883,0.007427116,0.00006701395,0.001529927,0.00009579826,0.000293774,0.001269862,0.005415754,0.03654786,0.9467705],"study_design_scores_gemma":[0.00001494181,0.00006000562,0.0009636619,0.007630841,0.0001275229,0.01277366,0.0001438329,0.0001624716,0.0005290518,0.004773328,0.9727919,0.00002879831],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002474449,0.9955836,0.0004347198,0.001773903,0.0002835912,0.000003633717,0.00002426005,0.0000157472,0.001633068],"genre_scores_gemma":[0.001752727,0.9953446,0.0009462704,0.0008694217,0.0004997441,0.000006311014,0.00006240502,0.000004518864,0.0005141043],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002448671,"threshold_uncertainty_score":0.008191645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02966836299017711,"score_gpt":0.3214237362527727,"score_spread":0.2917553732625956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}