{"id":"W3096222995","doi":"10.1182/blood-2020-134977","title":"ASXL1-Mutant Chronic Myelomonocytic Leukemia Is Associated with Increased Intratumoral Heterogeneity and Single-Cell Chromatin Co-Accessibility","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Biology; Chromatin; Epigenomics; Computational biology; Genetics; Molecular biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444139,0.0001799413,0.0001704547,0.000389787,0.0001564067,0.0002907451,0.0001064514,0.0002161093,0.001529086],"category_scores_gemma":[0.000134576,0.0001255562,0.0001053884,0.0002468002,0.0002321924,0.0001060524,0.0002280307,0.000268348,0.0002612098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031072,"about_ca_system_score_gemma":0.0001027478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003528558,"about_ca_topic_score_gemma":0.0005633351,"domain_scores_codex":[0.9998017,0.00001650841,0.00001105703,0.00007969751,0.00005701969,0.00003410202],"domain_scores_gemma":[0.9998049,0.00003112295,0.00007997537,0.00002264919,0.00001706896,0.00004432001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001845623,0.00001554552,0.006366429,0.00003580159,0.00001322683,0.0004589472,0.00003963861,0.00007921951,0.9905002,0.00008738372,0.0001096322,0.002109532],"study_design_scores_gemma":[0.00005036326,0.0003601849,0.2689359,0.00001799041,0.00007583412,0.01580324,0.0001708191,0.00274758,0.704084,0.0004654875,0.007268723,0.00001981132],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962256,0.000752648,0.00193823,0.00004643654,0.000008053,0.00001159204,0.0003533786,0.00008513621,0.0005789489],"genre_scores_gemma":[0.998431,0.0001245172,0.0005676766,0.00002050814,0.000004797342,0.0000132011,0.0003860836,0.00001643664,0.0004358276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529086,"threshold_uncertainty_score":0.00511533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02894232841328798,"score_gpt":0.2760798517510641,"score_spread":0.2471375233377762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}