{"id":"W3096231293","doi":"10.1016/s0959-8049(20)31126-6","title":"The integrated stress response exposes a therapeutic vulnerability in KRAS driven lung cancer","year":2020,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"KRAS; Lung cancer; Integrated stress response; Cancer research; Biology; Reprogramming; Adenocarcinoma; Cancer; Cellular stress response; Adaptation (eye); Mutation; Medicine; Fight-or-flight response; Gene; Oncology; Genetics; Translation (biology); Messenger RNA; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001779125,0.0001204772,0.0003359074,0.00005904918,0.00006609395,0.00002790456,0.0002601788,0.00001890057,0.0002635608],"category_scores_gemma":[0.00168868,0.00006872372,0.0001222735,0.0001945868,0.0001708717,0.00007698739,0.00005204148,0.0007571942,0.000004951803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857478,"about_ca_system_score_gemma":0.0003176955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007079032,"about_ca_topic_score_gemma":0.000198139,"domain_scores_codex":[0.9959438,0.002748787,0.0005650842,0.00014872,0.0002652515,0.0003283622],"domain_scores_gemma":[0.9989286,0.0001804303,0.0002104416,0.0001405619,0.0002638414,0.0002761118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.032226,0.0001016253,0.7864028,0.00007604446,0.0003439762,0.001437891,0.001694951,0.001267156,0.04667994,0.000006925855,0.0141458,0.1156169],"study_design_scores_gemma":[0.003170833,0.001902626,0.9168264,0.0006146945,0.00005503636,0.00006182781,0.0005458553,0.00178675,0.0007379682,0.000006112209,0.07419687,0.00009500701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351401,0.01212455,0.0001747272,0.05201554,0.0001885509,0.0001596112,0.00001868423,0.000009517657,0.0001687424],"genre_scores_gemma":[0.9922767,0.004304775,0.0000846526,0.002717088,0.0004151582,0.000007109263,0.000001006919,0.00002295064,0.0001706166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1304236,"threshold_uncertainty_score":0.3289674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04810686843482807,"score_gpt":0.3753494681346864,"score_spread":0.3272425996998584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}