{"id":"W3096247510","doi":"10.1158/0008-5472.can-20-1287","title":"Chromatin Looping Shapes KLF5-Dependent Transcriptional Programs in Human Epithelial Cancers","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; McGill University Health Centre","funders":"National Cancer Institute; Fonds de Recherche du Québec - Santé; Fondation du cancer des Cèdres; Fondation de l'Hôpital Général de Montréal; Broad Institute; McGill University","keywords":"Chromatin; Biology; BRD4; Bromodomain; Transcription factor; YAP1; Cancer research; Chromatin immunoprecipitation; Cell biology; Hippo signaling pathway; RNA polymerase II; Acetylation; Gene; Genetics; Gene expression; Promoter; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006038997,0.0001696316,0.0001935448,0.0001257717,0.0001560195,0.00009367981,0.0005903541,0.0001696994,0.0005105071],"category_scores_gemma":[0.0001143937,0.0001693392,0.00008540027,0.0004227825,0.0002828275,0.00001222372,0.0002200389,0.000604744,0.00004009352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509654,"about_ca_system_score_gemma":0.0008874673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297561,"about_ca_topic_score_gemma":0.00274246,"domain_scores_codex":[0.9970977,0.0002771631,0.0002738283,0.0006519742,0.0008870744,0.0008122438],"domain_scores_gemma":[0.9992076,0.0000178442,0.00003296225,0.0002163102,0.0002346086,0.0002906701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001876246,0.00005275253,0.008053818,0.0001149815,0.00003776179,0.00001951785,0.0004354879,0.0001996264,0.9854535,0.00008381272,0.0009187058,0.004442443],"study_design_scores_gemma":[0.002892825,0.001370377,0.01374891,0.0002048641,0.000007701315,0.00000611593,0.001073778,0.0005194203,0.9297863,0.000148509,0.04965717,0.0005840422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951797,0.001243023,0.0001043743,0.002059794,0.00006676754,0.0006648377,0.00007544464,0.00002053483,0.0005855628],"genre_scores_gemma":[0.9975683,0.0003786672,0.00006229082,0.0001687357,0.0007355487,0.0004317886,0.000113756,0.00004510236,0.0004958108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05566719,"threshold_uncertainty_score":0.6905454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1456731154830737,"score_gpt":0.4044463156863431,"score_spread":0.2587732002032694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}