{"id":"W3096287117","doi":"10.7554/elife.54080","title":"Genetic profiling of protein burden and nuclear export overload","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science","keywords":"Overproduction; Nuclear export signal; Green fluorescent protein; Biology; Mutant; Nuclear protein; Cell biology; Saccharomyces cerevisiae; Protein subcellular localization prediction; Gene; Genetics; Cell nucleus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002093792,0.000498866,0.000315344,0.0005490863,0.0002396343,0.0004035386,0.0002699572,0.0003937084,0.001028314],"category_scores_gemma":[0.0001536164,0.0002290103,0.0002706303,0.0003894798,0.0003809437,0.0002683137,0.0005831948,0.0008643376,0.0004214552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003574418,"about_ca_system_score_gemma":0.0001837613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000749983,"about_ca_topic_score_gemma":0.001091008,"domain_scores_codex":[0.9997055,0.00003108663,0.00002601394,0.00009319042,0.00008690354,0.00005738799],"domain_scores_gemma":[0.9995438,0.0001070216,0.000156732,0.00005055798,0.00004806724,0.00009383792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000206297,0.00000577122,0.0001382747,0.000009927045,0.000002449608,0.00003177169,0.000009918064,0.00003403443,0.999463,0.00004192084,0.000009906578,0.0002322972],"study_design_scores_gemma":[0.000004028078,0.00007388713,0.008021932,0.000005107472,0.00001644992,0.0002920167,0.000064596,0.0009579435,0.9892144,0.00006915595,0.001272519,0.000008143004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770269,0.0008121974,0.01836295,0.0001488106,0.0000349381,0.00004524087,0.001774204,0.0002716405,0.001523055],"genre_scores_gemma":[0.9791996,0.0009257891,0.01241459,0.000109424,0.00001013741,0.000064887,0.001949228,0.0002172285,0.005109163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028314,"threshold_uncertainty_score":0.003440022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00720898884525399,"score_gpt":0.1989854386114341,"score_spread":0.1917764497661801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}