{"id":"W3096287117","doi":"10.7554/elife.54080","title":"Genetic profiling of protein burden and nuclear export overload","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science","keywords":"Overproduction; Nuclear export signal; Green fluorescent protein; Biology; Mutant; Nuclear protein; Cell biology; Saccharomyces cerevisiae; Protein subcellular localization prediction; Gene; Genetics; Cell nucleus; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002383411,0.00005981904,0.00007088949,0.000007562277,0.00002249538,0.000006231237,0.00004684049,0.0000607097,0.00002609483],"category_scores_gemma":[0.00003167655,0.00005623737,0.0000252396,0.0000285093,0.00002858312,0.000001495671,0.00005270288,0.00004007906,0.000006559045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001395753,"about_ca_system_score_gemma":0.00001398728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005665656,"about_ca_topic_score_gemma":3.916226e-7,"domain_scores_codex":[0.9995909,0.00001051886,0.0000971728,0.0001553462,0.00007368236,0.00007232493],"domain_scores_gemma":[0.999782,7.96743e-7,0.00004064124,0.00009674854,0.00002751204,0.00005231059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005767225,0.000002456305,0.0009320757,0.00002480401,0.0000143121,0.000001413154,0.00009457399,0.000004525298,0.9955607,0.00007974276,0.0003729866,0.002854706],"study_design_scores_gemma":[0.0006482006,0.0008602889,0.01133487,0.00001615928,0.00002449172,0.00001760205,0.0003146304,0.0003574062,0.8228446,0.0000336732,0.1633176,0.0002304782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983507,0.0003498261,0.0001102108,0.0001773512,0.00003048843,0.0001233591,0.00000379589,0.000009263054,0.0008449621],"genre_scores_gemma":[0.9957624,0.00004100528,0.003407613,0.0002890104,0.000428967,0.000002332231,0.000007038334,0.00001389493,0.00004772384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1727162,"threshold_uncertainty_score":0.2293293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00720898884525399,"score_gpt":0.1989854386114341,"score_spread":0.1917764497661801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}