{"id":"W3096300067","doi":"10.1182/blood-2020-139025","title":"Lack of Effectiveness of Intravenous High-Dose Methotrexate for Prevention of CNS Relapse in Patients with High-Risk DLBCL: A Retrospective Analysis from Alberta, Canada","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Methotrexate; Diffuse large B-cell lymphoma; Guideline; Retrospective cohort study; Primary central nervous system lymphoma; Lymphoma; Oncology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840995,0.0004711966,0.0008253731,0.002206473,0.001553408,0.001857228,0.00175879,0.0005850802,0.001373755],"category_scores_gemma":[0.005309885,0.000523555,0.001080611,0.005972099,0.0009735136,0.0003158407,0.0007208542,0.0007269689,0.0001806627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02278201,"about_ca_system_score_gemma":0.0286039,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9388725,"about_ca_topic_score_gemma":0.9540222,"domain_scores_codex":[0.9965693,0.0003989946,0.0004797781,0.0005410649,0.001384911,0.0006259086],"domain_scores_gemma":[0.9889915,0.001116335,0.00410827,0.0004961965,0.003605423,0.001682379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000228119,0.00003142755,0.9969119,0.00008312741,0.000180747,0.0002130655,0.0001596633,0.00006071004,0.0001042842,0.00003457808,0.0003651307,0.001627269],"study_design_scores_gemma":[0.00004954473,0.00009264325,0.9971861,0.0001114614,0.0002937314,0.0004774099,0.0006186002,0.0002237041,0.00007513456,0.0000132405,0.0008416967,0.00001662113],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881538,0.005608368,0.0001387919,0.0003541764,0.00002773821,0.0001105521,0.003525821,0.00001317821,0.002067713],"genre_scores_gemma":[0.9965328,0.001450354,0.0001438014,0.000274562,0.00001989389,0.000022575,0.001337391,0.000008459297,0.0002102347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06112748,"threshold_uncertainty_score":0.1652958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008229019698757953,"score_gpt":0.2323607925719577,"score_spread":0.2241317728731998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}