{"id":"W3096307008","doi":"10.1182/blood-2020-137574","title":"Impact of Prior Therapies on the Safety and Efficacy of Once Weekly Selinexor, Bortezomib, and Dexamethasone Compared with Twice Weekly Bortezomib and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Results from the Boston Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary; University of Alberta","funders":"","keywords":"Bortezomib; Dexamethasone; Multiple myeloma; Medicine; Carfilzomib; Refractory (planetary science); Internal medicine; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002248545,0.0004170984,0.001230469,0.0002862538,0.0001973761,0.0008772789,0.0004091559,0.0006263345,0.002300831],"category_scores_gemma":[0.001756332,0.0001681965,0.001767348,0.0003225847,0.0003341712,0.0005210959,0.0003583845,0.001308487,0.0004426647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019674,"about_ca_system_score_gemma":0.0004526122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109939,"about_ca_topic_score_gemma":0.00319481,"domain_scores_codex":[0.998758,0.0005509711,0.0001068475,0.0002016142,0.0002656155,0.0001169923],"domain_scores_gemma":[0.9982184,0.0005078324,0.0006214704,0.0001309695,0.0001263733,0.0003948715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5991946,0.007186152,0.1457402,0.0007852682,0.00895488,0.0002087524,0.0003901687,0.001520304,0.01620028,0.0002037724,0.002950211,0.2166654],"study_design_scores_gemma":[0.08979204,0.3772691,0.5085936,0.0002570447,0.007229953,0.0004802979,0.0001930962,0.001293954,0.004723425,0.0003301891,0.009760931,0.00007640414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844625,0.01278901,0.00008766333,0.0003659965,0.00005261965,0.00009759761,0.0007313772,0.00001568526,0.001397647],"genre_scores_gemma":[0.9956849,0.001822861,0.00009853007,0.0003260782,0.0000893761,0.00006458131,0.0010497,0.000006829916,0.0008571752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300831,"threshold_uncertainty_score":0.01189154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04795140748015782,"score_gpt":0.3135839291236633,"score_spread":0.2656325216435055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}