{"id":"W3096311199","doi":"10.1001/jamanetworkopen.2020.22847","title":"Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With <i>MAPT</i>, <i>GRN</i>, and <i>C9orf72</i> Pathogenic Variants","year":2020,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of British Columbia","funders":"National Institute on Aging; National Institutes of Health; Larry L. Hillblom Foundation","keywords":"Frontotemporal lobar degeneration; C9orf72; Frontotemporal dementia; Atrophy; Clinical Dementia Rating; Dementia; Semantic dementia; Dementia with Lewy bodies; Psychology; Medicine; Disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246847,0.0003222112,0.0002723093,0.0009102998,0.0003233141,0.0003788594,0.00040077,0.0003682811,0.0008097601],"category_scores_gemma":[0.00240036,0.0002482573,0.0003706604,0.0003897554,0.0003710086,0.0003698614,0.0003339104,0.0003145192,0.0001003769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004300305,"about_ca_system_score_gemma":0.000180823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005372166,"about_ca_topic_score_gemma":0.008093485,"domain_scores_codex":[0.9995729,0.0001215353,0.00003720093,0.0001684606,0.0000652883,0.00003462644],"domain_scores_gemma":[0.9988077,0.0002354094,0.0006101429,0.0001242586,0.0001112836,0.0001112645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001387502,0.00008182111,0.9921803,0.00002332348,0.0002002381,0.0001478883,0.0001868774,0.0001249708,0.001501352,0.0000340351,0.0001283552,0.004003412],"study_design_scores_gemma":[0.00002452295,0.0002227547,0.9987189,0.000004235676,0.0000561111,0.0003087436,0.00005041806,0.000238959,0.0002756162,0.00004187896,0.00005466882,0.000003408496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994216,0.0001888409,0.00008837813,0.000008442012,0.000001510505,0.00001028239,0.0001330887,0.000003982966,0.0001438183],"genre_scores_gemma":[0.999624,0.00004292417,0.0001020944,0.000005781912,0.000002547164,0.000009048309,0.0001553953,0.000001184719,0.00005699326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005372166,"threshold_uncertainty_score":0.01068181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867419773405053,"score_gpt":0.3138932084722447,"score_spread":0.2752190107381942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}