{"id":"W3096340533","doi":"10.3389/fgene.2020.558762","title":"Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; National Institute for Health and Care Research; European Commission; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; Cancer Research Institute; California Dairy Research Foundation; U.S. Department of Agriculture","keywords":"Haplotype; Lactase; Lactose intolerance; Biology; Genetics; Single-nucleotide polymorphism; Allele; Disease; Gene; Genotype; Lactose; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001384678,0.00006387495,0.0001000793,0.00002303279,0.00002248649,0.000002474178,0.0001155131,0.00004774437,6.777578e-7],"category_scores_gemma":[0.0001154779,0.00004805833,0.00003771749,0.0001562835,0.00004028168,0.00000123591,0.00003888781,0.00007890092,4.444411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002787854,"about_ca_system_score_gemma":0.00008044467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001537871,"about_ca_topic_score_gemma":0.00005683633,"domain_scores_codex":[0.9992512,0.0001941584,0.0002020984,0.0001364288,0.0001125508,0.0001035227],"domain_scores_gemma":[0.9995433,0.000003470525,0.0001921593,0.0001500133,0.00005405483,0.00005698307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007374469,0.00004826957,0.9891146,0.00003940658,0.00002109103,0.000001127214,0.0002253856,0.008058653,0.001412133,0.000004371924,0.0008520371,0.0001491494],"study_design_scores_gemma":[0.0005298018,0.0001441851,0.9941228,0.00006493711,0.00004793634,2.425326e-7,0.0002320306,0.0009471705,0.002837484,0.00001227125,0.0009852513,0.00007588835],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969525,0.001389022,0.0005571712,0.0003654596,0.0001335861,0.0002082976,0.0000520623,0.000002122291,0.0003398185],"genre_scores_gemma":[0.9980352,0.0003779714,0.001403189,0.00005776329,0.0000266966,0.000001633517,0.00001484419,0.00001027836,0.00007240296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007111483,"threshold_uncertainty_score":0.1959762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399388620705838,"score_gpt":0.2175191677664041,"score_spread":0.2035252815593458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}