{"id":"W3096343174","doi":"10.1101/2020.10.29.360552","title":"Amyloid ß Impacts Future Freezing of Gait in Parkinson’s Disease Via White Matter Hyperintensities","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Women and Children’s Health Research Institute; University of Alberta; Centres Intégré Universitaires de Santé et de Services Sociaux","funders":"Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer Society Research Program; Genentech; H. Lundbeck A/S; Bristol-Myers Squibb; Eli Lilly and Company; Alzheimer Society; Biogen; GlaxoSmithKline; Sanofi; Michael J. Fox Foundation for Parkinson's Research","keywords":"Putamen; Hyperintensity; Atrophy; White matter; Pittsburgh compound B; Substantia nigra; Internal medicine; Amyloid (mycology); Parkinson's disease; Medicine; Pathology; Cerebrospinal fluid; Psychology; Dopamine transporter; Cardiology; Neuroscience; Magnetic resonance imaging; Dementia; Disease; Dopamine; Dopaminergic; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004956125,0.0004877757,0.0002659705,0.0003226431,0.0002696092,0.0005969979,0.0001741198,0.0002731502,0.001605836],"category_scores_gemma":[0.001485451,0.0001867683,0.0004773722,0.0002300265,0.0003198726,0.0003277646,0.0004532121,0.0004283567,0.0001011604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756846,"about_ca_system_score_gemma":0.000259879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003167321,"about_ca_topic_score_gemma":0.003747223,"domain_scores_codex":[0.9998635,0.00004766718,0.00001504807,0.00002855742,0.0000201304,0.00002506127],"domain_scores_gemma":[0.9993381,0.0001568874,0.000330341,0.00004256605,0.00005489085,0.0000771613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001911314,0.0004923891,0.9700305,0.0001039503,0.0008076798,0.0007861193,0.0002564242,0.001034488,0.006503241,0.0002426382,0.0002869758,0.01754427],"study_design_scores_gemma":[0.0000142792,0.0003683924,0.997348,0.00001782304,0.0001363033,0.0002903069,0.00008832439,0.0009186877,0.0003719795,0.0003341922,0.0001066916,0.000005056026],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987488,0.0002796456,0.0002105086,0.0000751582,0.000006521664,0.000008326187,0.00009775535,0.000008030862,0.0005653196],"genre_scores_gemma":[0.9995664,0.00008405784,0.0001357818,0.00001906407,0.000004571905,0.000003675212,0.00006830043,9.602315e-7,0.0001172768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003167321,"threshold_uncertainty_score":0.006297767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126912506545981,"score_gpt":0.2205998451217903,"score_spread":0.2079085944671922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}