{"id":"W3096383113","doi":"10.1182/blood-2020-137572","title":"A Multicenter Phase 1/2 Clinical Trial of Tagraxofusp, a CD123-Targeted Therapy, in Patients with Poor-Risk Primary and Secondary Myelofibrosis","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myelofibrosis; Internal medicine; Ruxolitinib; Oncology; Phases of clinical research; Clinical trial; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002412425,0.002086434,0.001862268,0.0004028689,0.0006398866,0.001075445,0.0008958303,0.001716468,0.005654571],"category_scores_gemma":[0.0009751126,0.0007098169,0.001249441,0.0003761386,0.001205495,0.001192519,0.0004492908,0.003113609,0.001331347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000784888,"about_ca_system_score_gemma":0.002094591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665635,"about_ca_topic_score_gemma":0.001458924,"domain_scores_codex":[0.9993607,0.0003278822,0.00003206818,0.0001135536,0.00004844127,0.0001173541],"domain_scores_gemma":[0.999297,0.00006916924,0.0001171122,0.00006636898,0.00005549791,0.0003948061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8158494,0.08038498,0.004082378,0.0007171771,0.0008180772,0.0003148756,0.0001929113,0.001474769,0.04404504,0.0004546687,0.007150461,0.04451516],"study_design_scores_gemma":[0.715864,0.2766518,0.002675257,0.00002412482,0.0001866226,0.0001790663,0.00002082341,0.000513898,0.00193821,0.0001889921,0.001740062,0.00001716239],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727114,0.002230327,0.001394354,0.001967822,0.0003894056,0.01459523,0.002808681,0.0001808093,0.003721921],"genre_scores_gemma":[0.9648149,0.001634782,0.004437532,0.002688868,0.0005085106,0.01636686,0.004627801,0.00005216572,0.004868605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005654571,"threshold_uncertainty_score":0.01891643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269525113218795,"score_gpt":0.2888989259235585,"score_spread":0.2662036747913705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}