{"id":"W3096476504","doi":"10.1016/j.scr.2020.102075","title":"Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Biodiversity Institute of Ontario","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; SOX2; KLF4; Retinitis pigmentosa; Mutation; Peripheral blood mononuclear cell; Genetics; Gene; Cancer research; Molecular biology; Embryonic stem cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002088124,0.00009055159,0.0001006793,0.00004103642,0.00009808961,0.00003213744,0.0001463254,0.00007817121,0.00003346464],"category_scores_gemma":[0.00001506244,0.00007859134,0.00003066526,0.0001618191,0.00008196993,0.000004700757,0.0000813323,0.00009558786,0.00001673322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007638664,"about_ca_system_score_gemma":0.0001077215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000152357,"about_ca_topic_score_gemma":0.0001821455,"domain_scores_codex":[0.9988675,0.00009989463,0.000176467,0.0002955637,0.0003762423,0.0001843666],"domain_scores_gemma":[0.9994612,0.00001746172,0.00005425686,0.0001548065,0.0002366814,0.0000756162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001555626,0.0000278278,0.007128295,0.00003892602,0.00002106469,0.000006540154,0.0002711736,0.00002787499,0.9872553,0.00003312444,0.002400227,0.002634042],"study_design_scores_gemma":[0.0009649005,0.001171545,0.009680938,0.00002512138,0.000009874769,6.013894e-7,0.001046171,0.0004603026,0.9819574,0.00008335335,0.004425695,0.0001741309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904161,0.000584682,0.001031202,0.0002643008,0.00001991874,0.0002448714,0.00001314182,0.000006891463,0.007418886],"genre_scores_gemma":[0.9982129,0.0001272038,0.0005174848,0.00006482993,0.0001651344,0.0000246945,0.0004404873,0.00001625326,0.0004310375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007796769,"threshold_uncertainty_score":0.3204862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1450701885500739,"score_gpt":0.3333269710387326,"score_spread":0.1882567824886587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}