{"id":"W3096476504","doi":"10.1016/j.scr.2020.102075","title":"Generation of three human iPSC lines from a retinitis pigmentosa family with SLC7A14 mutation","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Biodiversity Institute of Ontario","keywords":"Biology; Induced pluripotent stem cell; Reprogramming; SOX2; KLF4; Retinitis pigmentosa; Mutation; Peripheral blood mononuclear cell; Genetics; Gene; Cancer research; Molecular biology; Embryonic stem cell; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915143,0.0003046938,0.000381313,0.0007288085,0.0005100189,0.0004694189,0.0003557612,0.0006274063,0.003506728],"category_scores_gemma":[0.0004230181,0.0001585571,0.0005290143,0.0004207918,0.0002406142,0.0001682669,0.0004395388,0.0006992955,0.001136945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865405,"about_ca_system_score_gemma":0.0003063021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008858108,"about_ca_topic_score_gemma":0.001049978,"domain_scores_codex":[0.9997283,0.00002154355,0.00007011015,0.00004845548,0.00009615465,0.00003549802],"domain_scores_gemma":[0.9997696,0.0000455563,0.00001806782,0.00005590246,0.00005930984,0.00005143697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000334069,0.000145216,0.004537721,0.0001779699,0.00006149114,0.004661911,0.0005448517,0.000322685,0.9677995,0.001105724,0.001264191,0.01904466],"study_design_scores_gemma":[0.0001829507,0.0005227636,0.01822863,0.00008172377,0.0002991596,0.02165121,0.0003827798,0.002215172,0.917635,0.0004884668,0.03824547,0.00006673967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400539,0.002526942,0.03213237,0.0005078937,0.0003374967,0.001106601,0.009963213,0.000659937,0.01271151],"genre_scores_gemma":[0.9259694,0.003245539,0.03541756,0.0004949113,0.00007977323,0.001147234,0.02305433,0.0001709963,0.01042014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003506728,"threshold_uncertainty_score":0.01173115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1450701885500739,"score_gpt":0.3333269710387326,"score_spread":0.1882567824886587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}