{"id":"W3096523604","doi":"10.1093/narcan/zcaa032","title":"The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability","year":2020,"lang":"en","type":"article","venue":"NAR Cancer","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Transcription (linguistics); DNA; RNA; RNA polymerase I; Ribosome biogenesis; Molecular biology; RNA polymerase II; Promoter; Cancer research; Polymerase; Cell biology; Ribosome; Genetics; Gene expression; Gene; RNA-dependent RNA polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001459088,0.0001385512,0.0001020239,0.00001309966,0.0001743891,0.00005157739,0.00009992662,0.00009974588,0.00005679592],"category_scores_gemma":[0.00004963811,0.0001098802,0.00003518205,0.00006996565,0.00005755823,0.00000789879,0.00008336274,0.00007265231,0.000005059517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001815387,"about_ca_system_score_gemma":0.0000482087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003640112,"about_ca_topic_score_gemma":0.00003313141,"domain_scores_codex":[0.9991453,0.00008703135,0.0001424439,0.0003442519,0.000108565,0.0001724243],"domain_scores_gemma":[0.9994848,0.00001497579,0.00005994307,0.0002233236,0.00004491809,0.000172042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001684167,0.00002298769,0.0007090507,0.00003721161,0.00002886599,0.000002188545,0.0005073549,0.000002904006,0.9841887,0.000007522112,0.000710479,0.01361434],"study_design_scores_gemma":[0.0004627642,0.0002321774,0.001661485,0.00001404989,0.00004477828,0.000001988309,0.0001116172,0.00009508774,0.9512453,0.00006191559,0.04587886,0.0001899865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990101,0.00216081,0.0003650438,0.00675082,0.0000751395,0.0004230874,0.00002972738,0.00001158554,0.000082791],"genre_scores_gemma":[0.9937006,0.0008314199,0.000160505,0.004828323,0.0001684382,0.00005507284,0.00001001875,0.00002074913,0.0002249002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04516838,"threshold_uncertainty_score":0.4480783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628509276239699,"score_gpt":0.2495479206906361,"score_spread":0.2332628279282391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}