{"id":"W3096538903","doi":"10.1182/blood-2020-134847","title":"Updated Analysis of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM): The Phase 3 Maia Study","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Lenalidomide; Daratumumab; Internal medicine; Multiple myeloma; Transplantation; Minimal residual disease; Phases of clinical research; Oncology; Surgery; Chemotherapy; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003753528,0.0007125007,0.002151008,0.0004473217,0.0002839686,0.001203832,0.0009186075,0.0007619972,0.002635221],"category_scores_gemma":[0.003138766,0.0004120389,0.004503349,0.0007829902,0.0003422385,0.0008071997,0.0005305419,0.002339178,0.0004385511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088991,"about_ca_system_score_gemma":0.001286903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008505296,"about_ca_topic_score_gemma":0.002835876,"domain_scores_codex":[0.9986537,0.0007015434,0.0001383875,0.0002071975,0.000186477,0.0001128678],"domain_scores_gemma":[0.9967009,0.0009316859,0.001231622,0.0002434677,0.0002482997,0.0006438717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7910949,0.004279341,0.06431977,0.001625129,0.02006027,0.0001685992,0.0001862188,0.003119238,0.007409521,0.0003647611,0.007398407,0.0999739],"study_design_scores_gemma":[0.4614638,0.1960139,0.27576,0.0004716526,0.03788016,0.0007334763,0.0001676941,0.004787985,0.003431794,0.001064063,0.01808363,0.0001418747],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675731,0.01698321,0.0007718311,0.001355012,0.000302058,0.001016842,0.008962693,0.00007013945,0.002965106],"genre_scores_gemma":[0.9835168,0.002921667,0.001124556,0.001666408,0.0002635141,0.0008967835,0.008702483,0.00002306149,0.0008847399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003753528,"threshold_uncertainty_score":0.01985079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02812058088858904,"score_gpt":0.2912251193874986,"score_spread":0.2631045384989096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}