{"id":"W3096607082","doi":"10.1182/blood-2020-134449","title":"Interim Analysis of ZUMA-12: A Phase 2 Study of Axicabtagene Ciloleucel (Axi-Cel) as First-Line Therapy in Patients (Pts) With High-Risk Large B Cell Lymphoma (LBCL)","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Interim; Medicine; Internal medicine; Lymphoma; Oncology; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000360453,0.0003116537,0.001161861,0.000587111,0.00004805729,0.00001406467,0.0003226968,0.0001079192,0.001564433],"category_scores_gemma":[0.00008934707,0.000245821,0.0002374864,0.001943511,0.00007791494,0.00006357303,0.0001322012,0.0002371158,0.0000124798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006472396,"about_ca_system_score_gemma":0.0001342082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455028,"about_ca_topic_score_gemma":0.0006128338,"domain_scores_codex":[0.9970645,0.0002213168,0.000758447,0.0005859553,0.0009530771,0.0004167389],"domain_scores_gemma":[0.9982237,0.0001185657,0.0003553008,0.0007547117,0.0002870613,0.0002606567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01966217,0.1670957,0.7367646,0.0001961014,0.006596209,0.0002265963,0.0118225,0.00008151833,0.04013709,0.000002848115,0.00005814644,0.01735653],"study_design_scores_gemma":[0.377046,0.09687065,0.2940845,0.0001221626,0.004260133,0.000003040716,0.002136633,0.001279345,0.2229796,0.000007341027,0.0007038038,0.0005068064],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976434,0.0002569014,0.00003553004,0.0001027506,0.00002480023,0.001372728,0.0001329315,0.00003442296,0.0003965658],"genre_scores_gemma":[0.9988442,0.0003858532,0.00007613079,0.0001581647,0.00005950668,0.0000607963,0.0001260708,0.00006135812,0.0002279048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4426801,"threshold_uncertainty_score":0.9999994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507145883044169,"score_gpt":0.2994249819224932,"score_spread":0.2743535230920515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}