{"id":"W3096607082","doi":"10.1182/blood-2020-134449","title":"Interim Analysis of ZUMA-12: A Phase 2 Study of Axicabtagene Ciloleucel (Axi-Cel) as First-Line Therapy in Patients (Pts) With High-Risk Large B Cell Lymphoma (LBCL)","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Interim; Medicine; Internal medicine; Lymphoma; Oncology; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004437069,0.001132197,0.001675942,0.0004227097,0.000416971,0.001266198,0.000712738,0.0009169744,0.005448905],"category_scores_gemma":[0.0027175,0.0004944788,0.00212499,0.0003428766,0.0004731633,0.000832762,0.0004798828,0.003127815,0.00120897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005231041,"about_ca_system_score_gemma":0.001344333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002670056,"about_ca_topic_score_gemma":0.0007339249,"domain_scores_codex":[0.9991783,0.0004138154,0.00003921116,0.0001056663,0.0001106595,0.0001523281],"domain_scores_gemma":[0.9986849,0.0002746282,0.0003601454,0.0001975102,0.0001212015,0.0003615822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7922246,0.01923831,0.02157374,0.001231578,0.005010478,0.0005296449,0.000238839,0.005918561,0.0287205,0.0008528985,0.01548852,0.1089724],"study_design_scores_gemma":[0.393922,0.4933528,0.06222673,0.0001670889,0.006788137,0.001632883,0.0001760813,0.006850125,0.0116159,0.001909505,0.02125531,0.0001032999],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702495,0.00435668,0.003816618,0.0009908821,0.0003472665,0.00425887,0.008317716,0.0005417657,0.007120783],"genre_scores_gemma":[0.9655313,0.001378512,0.006479195,0.001601136,0.0001835441,0.006023031,0.01386899,0.000134104,0.004800136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005448905,"threshold_uncertainty_score":0.02346575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507145883044169,"score_gpt":0.2994249819224932,"score_spread":0.2743535230920515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}