{"id":"W3096609892","doi":"10.1182/blood-2020-133355","title":"Preliminary Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Subcutaneously (SC) Administered PF-06863135, a B-Cell Maturation Antigen (BCMA)-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Institute of Cancer Research; University of Alberta; McGill University Health Centre; University of Calgary","funders":"","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Refractory (planetary science); Multiple myeloma; Antibody; Pharmacology; Antigen; Internal medicine; Oncology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004875491,0.0004095222,0.000653672,0.0002077264,0.0002327874,0.0002972069,0.0002338242,0.0003198723,0.0008608564],"category_scores_gemma":[0.0005032704,0.0001873403,0.0006531753,0.000300825,0.0003349708,0.0002713628,0.0001522268,0.001189318,0.000273695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005091453,"about_ca_system_score_gemma":0.000482572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005697669,"about_ca_topic_score_gemma":0.001025078,"domain_scores_codex":[0.9998118,0.00006257054,0.00001633278,0.00003727801,0.00003585617,0.00003612827],"domain_scores_gemma":[0.9997886,0.00004468406,0.00005978567,0.00002333318,0.00001666495,0.00006689199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1786948,0.01948023,0.04477943,0.0009658839,0.0006182403,0.001113536,0.0007999406,0.008898547,0.3521909,0.0003319514,0.002658526,0.3894681],"study_design_scores_gemma":[0.01894309,0.6920893,0.1823524,0.00007672602,0.0009777126,0.002570154,0.0001274932,0.004307893,0.08938538,0.0003242815,0.008788971,0.00005653879],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959111,0.002100754,0.0005733187,0.0000773345,0.00001401247,0.0001888062,0.0002868717,0.00006314049,0.0007847249],"genre_scores_gemma":[0.9983045,0.0004072943,0.0004120684,0.00006210487,0.00001850028,0.00007568698,0.000386709,0.000006235107,0.0003269245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008608564,"threshold_uncertainty_score":0.003694117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532073475445875,"score_gpt":0.2673511792676903,"score_spread":0.2520304445132315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}