{"id":"W3096617937","doi":"10.1182/blood-2020-137700","title":"<i>Nfkbiz</i> 3′ UTR Mutations Confer Selective Growth Advantage and Affect Drug Response in Diffuse Large B-Cell Lymphoma","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Spinal Cord Injury BC; Simon Fraser University","funders":"","keywords":"Untranslated region; Biology; Diffuse large B-cell lymphoma; Three prime untranslated region; Mutation; Gene; Genetics; CRISPR; Cancer research; Molecular biology; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007642465,0.0001734126,0.0001602271,0.0001342024,0.00008444185,0.0001292957,0.00008898661,0.0002157512,0.001378561],"category_scores_gemma":[0.000090458,0.00005249771,0.0001420838,0.00008471695,0.000131973,0.00006468164,0.0001015109,0.0002155505,0.0003589506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805521,"about_ca_system_score_gemma":0.00007362138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004244719,"about_ca_topic_score_gemma":0.0004550254,"domain_scores_codex":[0.9999497,0.000007551006,0.000005948569,0.0000120965,0.0000109285,0.00001372474],"domain_scores_gemma":[0.9999381,0.00001259655,0.00001898507,0.000006392084,0.000004765026,0.00001916178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002348144,0.00003966626,0.004120094,0.00001784526,0.000007594163,0.0005428797,0.000007817815,0.00009275456,0.9924718,0.00006799879,0.00006293199,0.00233372],"study_design_scores_gemma":[0.0001151431,0.001343848,0.1791063,0.0000130128,0.00009556978,0.01903008,0.00006667253,0.002302289,0.7917395,0.0002356032,0.005931785,0.00002021044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982818,0.0004200889,0.0002670473,0.00003111804,0.000005433941,0.000005022948,0.0001407731,0.00003176763,0.0008168487],"genre_scores_gemma":[0.9993314,0.00008501247,0.0001677398,0.00002573342,0.000002458996,0.000003849153,0.0001474876,0.000005085647,0.0002312894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378561,"threshold_uncertainty_score":0.00461179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007595140182971929,"score_gpt":0.2390450535047009,"score_spread":0.231449913321729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}