{"id":"W3096648738","doi":"10.1007/s12192-020-01174-1","title":"Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK)","year":2020,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakes Environmental (Canada); University of Calgary; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Internal ribosome entry site; Cell biology; Eukaryotic initiation factor; ATF4; Integrated stress response; Unfolded protein response; Biology; Endoplasmic reticulum; Upstream open reading frame; Translational regulation; EIF-2 kinase; Downregulation and upregulation; Translation (biology); Kinase; Protein kinase A; Messenger RNA; Biochemistry; Cyclin-dependent kinase 2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714786,0.0004010797,0.0005045557,0.0003361561,0.0003005101,0.000357272,0.0001362499,0.0002503779,0.0009575557],"category_scores_gemma":[0.0001261513,0.0001568064,0.0005211073,0.0004781559,0.0001865569,0.0001512778,0.0002556393,0.000522129,0.000355661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699124,"about_ca_system_score_gemma":0.0002247245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007839631,"about_ca_topic_score_gemma":0.001272296,"domain_scores_codex":[0.9997815,0.00001328282,0.00001928886,0.00008612048,0.00006471123,0.00003507],"domain_scores_gemma":[0.9999279,0.00001277763,0.00002201432,0.000007544241,0.00001588208,0.00001390035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062518,0.00001641651,0.001053163,0.0001309477,0.0000150702,0.00003085137,0.0000136879,0.0001092324,0.9958709,0.00003533038,0.0001424951,0.002475618],"study_design_scores_gemma":[0.00002587849,0.0003150969,0.09043175,0.00003998969,0.000099504,0.0002719898,0.0001047487,0.002797493,0.8930641,0.0001431823,0.0126856,0.00002052459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671686,0.009365155,0.01004462,0.0002072014,0.0001777931,0.00006637743,0.01069,0.0003108154,0.001969449],"genre_scores_gemma":[0.9622244,0.004702683,0.009287809,0.0004430347,0.00003387803,0.0001544748,0.01884187,0.00009576798,0.00421607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009575557,"threshold_uncertainty_score":0.003203332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388661652276056,"score_gpt":0.2226490077916587,"score_spread":0.2087623912688981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}