{"id":"W3096667661","doi":"10.1021/acs.orglett.0c03113","title":"Controllable Tandem [3+2] Cyclization of Aromatic Aldehydes with Maleimides: Rhodium(III)-Catalyzed Divergent Synthesis of Indane-Fused Pyrrolidine-2,5-dione","year":2020,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"Indane; Chemistry; Pyrrolidine; Stereoselectivity; Tandem; Catalysis; Rhodium; Cascade reaction; Combinatorial chemistry; Organic chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002617986,0.0002826359,0.0006754157,0.00009789049,0.00007608634,0.0000245788,0.0003099649,0.0001177428,0.00354259],"category_scores_gemma":[0.0009306917,0.0002599002,0.0001246371,0.0006534467,0.0001643702,0.0001605796,0.00008195757,0.0001285426,0.0000255724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271484,"about_ca_system_score_gemma":0.0001331145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005583241,"about_ca_topic_score_gemma":0.00001046778,"domain_scores_codex":[0.9978865,0.00007044514,0.0007603663,0.0004118218,0.0006138498,0.000257064],"domain_scores_gemma":[0.9980664,0.0005306015,0.0006669587,0.0004538679,0.000133285,0.0001489069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002509457,0.00009275165,0.006821673,0.000424406,0.0003368864,0.000008018165,0.0006211096,0.0008685039,0.9891058,0.00004277549,0.001301476,0.0001256983],"study_design_scores_gemma":[0.002532835,0.00002843714,0.0007115773,0.0001718822,0.000409671,0.00001441877,0.0003667469,0.001617573,0.9935926,0.00002468837,0.0002465086,0.0002830584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679515,0.00007972265,0.02708423,0.003994975,0.00007879618,0.0002332987,0.00005382842,0.000130307,0.0003933051],"genre_scores_gemma":[0.9963257,0.00002882727,0.002318237,0.0009120848,0.0001250157,0.00002906773,0.0001255156,0.00006946644,0.00006607857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02837417,"threshold_uncertainty_score":0.9999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549443103943768,"score_gpt":0.2202790361116753,"score_spread":0.2047846050722376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}