{"id":"W3096683801","doi":"10.3390/cancers12113178","title":"RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; University of Toronto; McMaster University; Health Sciences Centre; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; Mitacs; National Cancer Institute; National Institutes of Health; CancerCare Manitoba Foundation; National Institute of Neurological Disorders and Stroke; Terry Fox Research Institute; Canada Foundation for Innovation; Research Manitoba; St. Jude Children's Research Hospital","keywords":"PTEN; RAD51; Homologous recombination; Olaparib; DNA repair; Cancer research; DNA damage; Gene knockdown; Biology; Synthetic lethality; PARP inhibitor; Genome instability; Molecular biology; Poly ADP ribose polymerase; DNA; Cell culture; Genetics; Polymerase; Apoptosis; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272797,0.0003888784,0.0002417114,0.0007785288,0.0001685759,0.0005067091,0.0002505288,0.0001692393,0.00296067],"category_scores_gemma":[0.0004159236,0.0001833522,0.0002799047,0.0003259137,0.0003116392,0.0002893316,0.0003241332,0.0002936591,0.0008917456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001815065,"about_ca_system_score_gemma":0.0002319452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004350073,"about_ca_topic_score_gemma":0.0006008945,"domain_scores_codex":[0.999702,0.00003153541,0.00002770343,0.00007647777,0.0001097482,0.00005252572],"domain_scores_gemma":[0.9996861,0.00003686066,0.000139554,0.00005031897,0.00003006604,0.00005708764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000257842,0.000037134,0.006780302,0.00009293001,0.00002619217,0.0005053254,0.00002398786,0.000101825,0.983965,0.000475249,0.0001489752,0.007585204],"study_design_scores_gemma":[0.00002478825,0.0005769283,0.1602881,0.00002518569,0.00009324026,0.006800964,0.00007124245,0.001146578,0.8235853,0.0004718056,0.006899585,0.00001641102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844884,0.002838141,0.004419146,0.0001376525,0.00003089893,0.00003825437,0.001460803,0.0003855258,0.006201245],"genre_scores_gemma":[0.9956469,0.0009494078,0.0003980821,0.00001797037,0.000005496011,0.00001922852,0.0006607383,0.00002139314,0.00228074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296067,"threshold_uncertainty_score":0.009904444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302493491512143,"score_gpt":0.2994024106940213,"score_spread":0.2663774757788999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}