{"id":"W3096683801","doi":"10.3390/cancers12113178","title":"RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; University of Toronto; McMaster University; Health Sciences Centre; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; Mitacs; National Cancer Institute; National Institutes of Health; CancerCare Manitoba Foundation; National Institute of Neurological Disorders and Stroke; Terry Fox Research Institute; Canada Foundation for Innovation; Research Manitoba; St. Jude Children's Research Hospital","keywords":"PTEN; RAD51; Homologous recombination; Olaparib; DNA repair; Cancer research; DNA damage; Gene knockdown; Biology; Synthetic lethality; PARP inhibitor; Genome instability; Molecular biology; Poly ADP ribose polymerase; DNA; Cell culture; Genetics; Polymerase; Apoptosis; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007398293,0.0001036917,0.0002218042,0.00007673532,0.00003038661,0.000005245844,0.00006165258,0.00008408272,0.001868207],"category_scores_gemma":[0.00009713956,0.0001062873,0.00006754041,0.0002873185,0.00009811069,0.00006952252,0.0000125957,0.0001567163,0.00005785526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001068563,"about_ca_system_score_gemma":0.001040804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171842,"about_ca_topic_score_gemma":0.000005739117,"domain_scores_codex":[0.998925,0.00003123197,0.0002738688,0.0002278994,0.000357459,0.0001845441],"domain_scores_gemma":[0.9992825,0.0000583768,0.0001601589,0.0001243026,0.0001880079,0.0001866702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007789617,0.000358538,0.05319159,0.001479057,0.001840649,0.0003690627,0.04450185,0.003303838,0.5488223,0.002679134,0.2496587,0.08600561],"study_design_scores_gemma":[0.04031995,0.00350668,0.1234917,0.0005432692,0.0003398275,0.0001470737,0.003660158,0.01252927,0.6810896,0.003559223,0.1297057,0.0011076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816285,0.0009471889,0.0005973227,0.00879061,0.0005009345,0.0005247614,0.0002855787,0.0001117481,0.006613322],"genre_scores_gemma":[0.9929754,0.0002998904,0.0002717582,0.005891787,0.0001419634,0.00003212638,0.0001880329,0.00002025855,0.0001787561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1322673,"threshold_uncertainty_score":0.9990442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302493491512143,"score_gpt":0.2994024106940213,"score_spread":0.2663774757788999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}