{"id":"W3096713005","doi":"10.1182/blood-2020-143408","title":"MRD Xenotransplantation Prospectively Identifies Treatment-Selected Acute Lymphoblastic Leukemia Subpopulations with Relapse-Initiating Potential","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Minimal residual disease; Medicine; Leukemia; Oncology; Acute lymphocytic leukemia; Population; Immunology; Lymphoblastic Leukemia; Transplantation; Internal medicine; Haematopoiesis; Acute leukemia; Cancer research; Stem cell; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003131913,0.0001878377,0.0003305653,0.0002984901,0.0001164256,0.0005306455,0.0001666477,0.0002112822,0.0007804125],"category_scores_gemma":[0.0003295546,0.0001209364,0.0001133161,0.0002048873,0.0002288688,0.0002190921,0.0002976683,0.0005226419,0.0003289093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916813,"about_ca_system_score_gemma":0.0001240571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001715275,"about_ca_topic_score_gemma":0.0002525094,"domain_scores_codex":[0.9998,0.00004313236,0.00001988737,0.00005007485,0.00004473151,0.00004213116],"domain_scores_gemma":[0.9998016,0.00005166847,0.0000440944,0.00005075113,0.00001287213,0.0000390951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002758458,0.0004234685,0.0901489,0.00005867489,0.00002597876,0.0004709594,0.0002371482,0.0006579859,0.8830073,0.0004348897,0.0003264525,0.02144969],"study_design_scores_gemma":[0.0001247586,0.007419874,0.4413546,0.00002930289,0.0001800989,0.009281196,0.0004017351,0.008167628,0.5242941,0.0003930338,0.008329629,0.00002396868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998552,0.000306243,0.0004090887,0.00001825058,0.000002785334,0.00001772176,0.0001438441,0.00003114362,0.0005188787],"genre_scores_gemma":[0.9981163,0.0002260726,0.0005824611,0.00003240563,0.000005298374,0.00002775017,0.0006707252,0.00001371781,0.0003252906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007804125,"threshold_uncertainty_score":0.002610683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593048465127211,"score_gpt":0.2572236571659911,"score_spread":0.241293172514719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}