{"id":"W3096713021","doi":"10.1182/blood-2020-134596","title":"Cost-Effectiveness of a 12-Month Fixed Duration of Venetoclax in Combination with Obinutuzumab Versus Chemoimmunotherapy and Other Novel Combinations in First-Line Chronic Lymphocytic Leukemia in Canada","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; ABB (Canada); McMaster University","funders":"","keywords":"Obinutuzumab; Venetoclax; Medicine; Chemoimmunotherapy; Chlorambucil; Ofatumumab; Ibrutinib; Bendamustine; Population; Chronic lymphocytic leukemia; Fludarabine; Internal medicine; Rituximab; Oncology; IGHV@; Leukemia; Cyclophosphamide; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983648,0.0001670493,0.000495923,0.0001952021,0.00001878439,0.000006317408,0.000111444,0.00009141333,0.00001423523],"category_scores_gemma":[0.0001952312,0.0001608522,0.00002589087,0.0007086814,0.00009749875,0.00008238606,0.00003619831,0.0001792305,4.654485e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1284787,"about_ca_system_score_gemma":0.06988309,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.73819,"about_ca_topic_score_gemma":0.8036136,"domain_scores_codex":[0.9984954,0.00008812609,0.0004795688,0.0002843071,0.0003946513,0.0002579594],"domain_scores_gemma":[0.9990003,0.0004498217,0.0001561088,0.0002238917,0.00009780491,0.00007206108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1106028,0.006523469,0.2306811,0.0235524,0.001928821,0.001215294,0.01966816,0.3537872,0.2376132,0.004122218,0.00005868773,0.01024665],"study_design_scores_gemma":[0.4975874,0.002433493,0.1014204,0.001543104,0.00007025887,0.00003640729,0.0003283577,0.3270003,0.06926868,0.00002330662,0.00004763277,0.000240659],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975513,0.0004251525,0.00007562112,0.00006672738,0.00002763599,0.001682028,0.00002018232,0.000009188043,0.0001422283],"genre_scores_gemma":[0.9995403,0.00008399905,0.00007812735,0.00003377467,0.0000115574,0.0001723914,0.00004286723,0.00002995019,0.000007090222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3869845,"threshold_uncertainty_score":0.9353898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03848499139418109,"score_gpt":0.2797604061445555,"score_spread":0.2412754147503744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}