{"id":"W3096713021","doi":"10.1182/blood-2020-134596","title":"Cost-Effectiveness of a 12-Month Fixed Duration of Venetoclax in Combination with Obinutuzumab Versus Chemoimmunotherapy and Other Novel Combinations in First-Line Chronic Lymphocytic Leukemia in Canada","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; ABB (Canada); McMaster University","funders":"","keywords":"Obinutuzumab; Venetoclax; Medicine; Chemoimmunotherapy; Chlorambucil; Ofatumumab; Ibrutinib; Bendamustine; Population; Chronic lymphocytic leukemia; Fludarabine; Internal medicine; Rituximab; Oncology; IGHV@; Leukemia; Cyclophosphamide; Chemotherapy; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002758432,0.001044493,0.001682821,0.001710166,0.0007493236,0.002230729,0.001608242,0.001139607,0.003239888],"category_scores_gemma":[0.01065877,0.0006774396,0.004867376,0.002582871,0.0006316849,0.0007947467,0.0008958568,0.001589838,0.0001074149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.08962183,"about_ca_system_score_gemma":0.05295458,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9379973,"about_ca_topic_score_gemma":0.924166,"domain_scores_codex":[0.9978693,0.001064151,0.0001162917,0.000205683,0.0003442643,0.0004002847],"domain_scores_gemma":[0.9968616,0.00137607,0.0004998946,0.00006325085,0.0007422085,0.0004568929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.04581326,0.001123094,0.08302853,0.01259503,0.02812996,0.000660574,0.000304797,0.6809486,0.001090682,0.009500707,0.01228105,0.1245237],"study_design_scores_gemma":[0.03496731,0.009992135,0.1982249,0.009515926,0.06639879,0.0008809363,0.001500929,0.647605,0.002649101,0.008338557,0.01932492,0.0006014509],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8604866,0.09522472,0.003727092,0.005773384,0.0002838104,0.001460446,0.02155428,0.0001302353,0.01135939],"genre_scores_gemma":[0.9847841,0.009965063,0.001414767,0.0003591669,0.00002573872,0.0001856386,0.002260951,0.00001588635,0.0009886246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08962183,"threshold_uncertainty_score":0.6502549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03848499139418109,"score_gpt":0.2797604061445555,"score_spread":0.2412754147503744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}